Optineurin (OPTN) (NM_021980) Human 3' UTR Clone

Specifications

Product Data
Product Name	Optineurin (OPTN) (NM_021980) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
ACCN	NM_021980
Insert Size	1440 bp
Sequence Data	Insert Sequence (showhide) >SC214448 3’UTR clone of NM_021980 The sequence shown below is from the reference sequence of NM_021980. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGATTCACGTGATGGATTGCATCATTTAAGTGTTGATGTATCACCTCCCCAAAACTGTTGGTAAATGT CAGATTTTTTCCTCCAAGAGTTGTGCTTTTGTGTTATTTGTTTTCACTCAAATATTTTGCCTCATTATT CTTGTTTTAAAAGAAAGAAAACAGGCCGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGG TCGAGGTGGGTGGATCACTTGGGGTCAGGGTTTGAGACCAGCCTGGCCAACATGGCGGAACCCTGTCTC TACCAAAATTACAAAAATTAGCCGAGCATGGTGGCGCATGCCTGTAGTCGCAGCTACTCGCGAGGTTGA GGCAGGAGAATTGCTTGAACCCAGGAAGTGGCAGTTGCAGTGAGCCGAGACGACACCACTGCACTCCAG CCTGGGTGACAGAGGGAGACTCTGTCTCGAAAGAAAGAAAGAAAAAAAGGAAGGAAGGAGAAGGAAGGA AGGAGAAGAAAAGGTACCTGTTCTACGTAGAACACCTTTGGTGGAGTTCCATCAACTCGCAAAGTAGAA TCCTTACCTACTACTCTTCTGATAATAATTTTAATATTTTTTATGTTTGGTTGATGCGAGCAGCTGCAC TGCTCATGCAGTTAGCTAGCATGTGACATCATGTGACAAAGTTCATGTAATTAGATGGAAGAAACCTCA CTGATTAATTTTAAGAACCTTTTAGGGATGCAGGAACAATGAAGTGGCCACAGTATGTGCTGTTTTTGA AGCATTTTTAAAAACGAATTGTAGTTGTTTTTCTTCATTTAAAATGGATCTGTTGGAGGTTATGTGTGT ATGTTGTAGTTTTATTGCAGCCACAATAATTTTACCAAAGTTTTCACATAGGCAGTTAGCCTTTACTTA ATATCAAGACAAGTGAAAAAATATTGGCATCGATGAAACCGATAACATTGGCCTCATTGGATTTCTTTA CCCATTCACAGTGTAAAGAAGTTACCTTCATGCTTTCATTGTACCTGCAGGCCTGTGGGCTTGTACAGT AGATAATTAATTTCTAAAAAGAACAGCTGCCTATTTTCTTCCTAGGTTAGGTTATATCTTCATAATCAC AAGAATTAGTGATGGCAAAATAAAATTTTGCTTATGAATCTTTTACATTGTTTATATATGATTAATATC ATCATATATATTTTCTGTATTAAGCTCATTTGGCTTCATTTAAGCTGTATACTTAGTCATATATCTTTC ATTAGTTCTATGGATATGAGCAGATCCCTTTACTGGAGCCCAGTATGTGCTGTGTGAGTTAGAAGTCAT TCTTGCTGAGAAGGTGAATAGGTAGGGATTTGCCTTGTTTTGTAAGTCTACAATTTGCCAAGAGTAAAT AACACTGGACCAGCTGTAAAAGTAAACAGTGTGTTTATGCATTGAGATACTAAAGCATTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_021980.4
Synonyms	ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
Summary	This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Locus ID	10133
MW	55

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