CXCR2 (NM_001557) Human 3' UTR Clone

Specifications

Product Data
Product Name	CXCR2 (NM_001557) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
ACCN	NM_001557
Insert Size	1397 bp
Sequence Data	Insert Sequence (showhide) >SC214255 3’UTR clone of NM_001557 The sequence shown below is from the reference sequence of NM_001557. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCTTCAGGGCACACTTCCACTACTCTCTAAGACCTCCTGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCT TCTCTTCACAGTCACATTCCAAGCCTCATGTCCACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGCCCC CATTGTGGTCACAGGAAGTAGAGGAGGCCACGTTCTTACTAGTTTCCCTTGCATGGTTTAGAAAGCTTG CCCTGGTGCCTCACCCCTTGCCATAATTACTATGTCATTTGCTGGAGCTCTGCCCATCCTGCCCCTGAG CCCATGGCACTCTATGTTCTAAGAAGTGAAAATCTACACTCCAGTGAGACAGCTCTGCATACTCATTAG GATGGCTAGTATCAAAAGAAAGAAAATCAGGCTGGCCAACGGGGTGAAACCCTGTCTCTACTAAAAATA CAAAAAAAAAAAAAAATTAGCCGGGCGTGGTGGTGAGTGCCTGTAATCACAGCTACTTGGGAGGCTGAG ATGGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCCCTGCACTCCAGC CTGAGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGTAGAGGAGAAACTGGAACTCTCGAGCGTTG CTGGGGGGGATTGTAAAATGGTGTGACCACTGCAGAAGACAGTATGGCAGCTTTCCTCAAAACTTCAGA CATAGAATTAACACATGATCCTGCAATTCCACTTATAGGAATTGACCCACAAGAAATGAAAGCAGGGAC TTGAACCCATATTTGTACACCAATATTCATAGCAGCTTATTCACAAGACCCAAAAGGCAGAAGCAACCC AAATGTTCATCAATGAATGAATGAATGGCTAAGCAAAATGTGATATGTACCTAACGAAGTATCCTTCAG CCTGAAAGAGGAATGAAGTACTCATACATGTTACAACACGGACGAACCTTGAAAACTTTATGCTAAGTG AAATAAGCCAGACATCAACAGATAAATAGTTTATGATTCCACCTACATGAGGTACTGAGAGTGAACAAA TTTACAGAGACAGAAAGCAGAACAGTGATTACCAGGGACTGAGGGGAGGGGAGCATGGGAAGTGACGGT TTAATGGGCACAGGGTTTATGTTTAGGATGTTGAAAAAGTTCTGCAGATAAACAGTAGTGATAGTTGTA CCGCAATGTGACTTAATGCCACTAAATTGACACTTAAAAATGGTTTAAATGGTCAATTTTGTTATGTAT ATTTTATATCAATTTAAAAAAAAACCTGAGCCCCAAAAGGTATTTTAATCACCAAGGCTGATTAAACCA AGGCTAGAACCACCTGCCTATATTTTTTGTTAAATGATTTCATTCAATATCTTTTTTTTAATAAACCAT TTTTACTTGGGTGTTTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001557.4
Synonyms	CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Summary	The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Locus ID	3579
MW	53.8

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