APLP2 (NM_001142278) Human 3' UTR Clone

Specifications

Product Data
Product Name	APLP2 (NM_001142278) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	APLP-2; APPH; APPL2; CDEBP
ACCN	NM_001142278
Insert Size	1387 bp
Sequence Data	Insert Sequence (showhide) >SC214249 3’UTR clone of NM_001142278 The sequence shown below is from the reference sequence of NM_001142278. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACAAATACCTGGAGCAGATGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGG TGGGCCGGAAGATCCCACGATTCCGATCGACTGCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTGACA TCCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCAATTTCCATTCTTTTAAAT GGGTGAAAAATGGTAATATAACAATATATGATATATAAACCTTAAATGAAAAAAATGATCTATTGCAGA TATTTGATGTAGTTTTCTTTTTTAAATTAATCAGAAACCCCACTTCCATTGTATTGTCTGACACATGCT CTCAATATATAATAAATGGGAAATGTCGATTTTCAATAATAGACTTATATGCAGGCTGTCGTTCCGGTT ATGTTGTGTAAGTCAACTCTTCAGCCTCATTCACTGTCCTGGCTTTTATTTAAAGAAAAAAAAGGCAGT ATTCCCTTTTTAAATGAGCTTTCAGGAAGTTGCTGAGAAATGGGGTGGAATAGGGAACTGTAATGGCCA CTGAAGCACGTGAGAGACCCTCGCAAAATGATGTGAAAGGACCAGTTTCTTGAAGTCCAGTGTTTCCAC GGCTGGATACCTGTGTGTCTCCATAAAAGTCCTGTCACCAAGGACGTTAAAGGCATTTTATTCCAGCGT CTTCTAGAGAGCTTAGTGTATACAGATGAGGGTGTCCGCTGCTGCTTTCCTTCGGAATCCAGTGCTTCC ACAGAGATTAGCCTGTAGCTTATATTTGACATTCTTCACTGTCTGTTGTTTACCTACCGTAGCTTTTTA CCGTTCACTTCCCCTTCCAACTATGTCCAGATGTGCAGGCTCCTCCTCTCTGGACTTTCTCCAAAGGCA CTGACCCTCGGCCTCTACTTTGTCCCCTCACCTCCACCCCCTCCTGTCACCGGCCTTGTGACATTCACT CAGAGAAGACCACACCAAGGAGGCGGCCGCTGGCCCAGGAGAGAACACGGGGAGGTTTGTTTGTGTGAA AGGAAAGTAGTCCAGGCTGTCCCTGAAACTGAGTCTGTGGACACTGTGGAAAGCTTTGAACAATTGTGT TTTCGTCACAGGAGTCTTTGTAATGCTTGTACAGTTGATGTCGATGCTCACTGCTTCTGCTTTTTCTTT CTTTTTATTTTAAATCTGAAGGTTCTGGTAACCTGTGGTGTATTTTTATTTTCCTGTGACTGTTTTTGT TTTGTTTTTTTCCTTTTTCCTCCCCTTTGACCCTATTCATGTCTCTACCCACTATGCACAGATTAAACT TCACCTACAAACTCCTTAATATGATCTGTGGAGAATGTACACAGTTTAAACACATCAATAAATACTTTA ACTTCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001142278.2
Synonyms	APLP-2; APPH; APPL2; CDEBP
Summary	This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Locus ID	334
MW	52.7

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