UHRF1 (NM_013282) Human 3' UTR Clone

Specifications

Product Data
Product Name	UHRF1 (NM_013282) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106; TDRD22
ACCN	NM_013282
Insert Size	1381 bp
Sequence Data	Insert Sequence (showhide) >SC214209 3’UTR clone of NM_013282 The sequence shown below is from the reference sequence of NM_013282. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTCTTCCCCGGCTACGGCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTTTTGCTGAAAACGT GTCGGAGGGCTCGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAGGTAGTGTTTCCT CCGTTCCCTAAAAAGGTTTGTCTTCCTTTTTTTTTTTATTTTTATTTTTCAAATCTATACATTTTCAGG AATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAACATAAAAGCC TGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGTGTGGAGGCT GTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAAGGCGACAGGATCAG TCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGACAGCATTTTGTCATCTAAAG TCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCATGGCGTGGCTCAGCTGTCTGTTGA AGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTTCAAACCTTTGCCTCAAAGCCATCCCCCAC CAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGTCCTCTGCCCACGAGAGCAGGGAGTTGGGGCCACG CAGAAATGGCCTCAAGGGGACTCTGCTCCACGTGGGGCCAGGCGTGTGACTGACGCTGTCCGACGAAGG CGGCCACGGACGGACGCCAGCACACGAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAAAG ACGACAGTCTTTGTTGTTAGCACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATCC AGTTCTTCCTGACACCGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTT TTTAACTCAGCAAGTGAGAACTTACAAGAGGGTTTTTTTAAAATTTTTTTTTCTCTTAATGAACACATT TTCTAAATGAATTTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGTTGT TTTTGTTTTTGTATTTTTTTTCTTTTGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTTGCAGC CTATACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAATGTTATTTTT AAAGGGTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAATGAGACAATTTTGTGT AGGCTTTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAATAAATGTTTTTCACAGATAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_013282.5
Synonyms	hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106; TDRD22
Summary	This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Locus ID	29128
MW	53

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