Phospholamban (PLN) (NM_002667) Human 3' UTR Clone

Specifications

Product Data
Product Name	Phospholamban (PLN) (NM_002667) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CMD1P; CMH18; PLB
ACCN	NM_002667
Insert Size	1365 bp
Sequence Data	Insert Sequence (showhide) >SC214206 3' UTR clone of NM_002667 The sequence shown below is from the reference sequence of NM_002667. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC GTATCATCGTGATGCTTCTCTGAAGTTCTGCTACAACCTCTAGATCTGCAGCTTGCCACATCAGCTTAAA ATCTGTCATCCCATGCAGACAGGAAAACAATATTGTATAACAGACCACTTCCTGAGTAGAAGAGTTTCTT TGTGAAAAGGTCAAGATTAAGACTAAAACTTATTGTTACCATATGTATTCATCTGTTGGATCTTGTAAAC ATGAAAAGGGCTTTATTTTCAAAAATTAACTTCAAAATAAGTGTATAAAATGCAACTGTTGATTTCCTCA ACATGGCTCACAAATTTCTATCCCAAATCTTTTCTGAAGATGAAGAGTTTAGTTTTAAAACTGCACTGCC AACAAGTTCACTTCATATATAAAGCATTATTTTTACTCTTTTGAGGTGAATATAATTTATATTACAATGT AAAAGCTTCTTTAATACTAAGTATTTTTCAGGTCTTCACCAAGTATCAAAGTAATAACACAAATGAAGTG TCATTATTCAAAATAGTCCACTGACTCCTCACATCTGTTATCTTATTATAAAGAACTATTTGTAGTAACT ATCAGAATCTACATTCTAAAACAGAAATTGTATTTTTTCTATGCCACATTAACATCTTTTAAAGTTGATG AGAATCAAGTATGGAAAAGTAAGGCCATACTCTTACATAATAAAATTCCTTTTAAGTAATTTTTTCAAAG AATCACAGAATTCTAGTACATGTAGGTAAATCATAAATCTGTTCTAAGACATATGATCAACAGATGAGAA CTGGTGGTTAATATGTGACAGTGAGATTAGTCATATCACTAATATACTAACAACAGAATCTAATCTTCAT TTAAGGCACTGTAGTGAATTATCTGAGCTAGAGTTACCTAGCTTACCATACTATATCTTTGGAATCATGA AACCTTAAGACTTCAGAATGATTTTGCAGGTTGTCTTCCATTCCAGCCTAACATCCAATGCAGGCAAGGA AAATAAAAGATTTCCAGTGACAGAAAAATATATTATCTCAAGTATTTTTTAAAAATATATGAATTCTCTC TCCAAATATTAACTAATTATTAGATTATATTTTGAAATGAACTTGTTGGCCCATCTATTACATCTACAGC TGACCCTTGAACATGGGGGTTAGGGGAGCTGACAATTCGTGGGTCCGCAAAATCTTAACTACCTAATAGC CTACTATTGACCATAAACCTTACTGATAACATAAACAGTAAATTAACACATATTTTGCGTGTTATATGTA TTATACACTATATTCCTACAATAAAGTAAGCTAGAGAAAATGTTATTTAGAAAATCATAAGAAAGAGAAA ATATATTTACTATTCATTAAATGGAAGTGGGTCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002667.3
Synonyms	CMD1P; CMH18; PLB
Summary	The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Locus ID	5350

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