Rb2 p130 (RBL2) (NM_005611) Human 3' UTR Clone

Specifications

Product Data
Product Name	Rb2 p130 (RBL2) (NM_005611) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	P130; Rb2
ACCN	NM_005611
Insert Size	1378 bp
Sequence Data	Insert Sequence (showhide) >SC214174 3’UTR clone of NM_005611 The sequence shown below is from the reference sequence of NM_005611. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATGTAGCTAATGACCGTGGTTCCCACTGAGGTTAGTCTCTTGTATTAAACTCTTCACAAAATCTGTTT AGCAGCAGCCTTTAATGCATCTAGATTATGGAGCTTTTTTCCTTAATCCAGCTGATGAGTTACAGCCTG TTAGTAACATGAGGGGACATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTT AATTCATCCCAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTAGAATCCAAAC TTGGATTTTTGACTCTGGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAAACGTGAGCA TAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTTCAAGTTCAATCCTACCTGTTTTGTGG TCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTATTTTGTCCTAAAACACCTGGTAGGAGTG TGTGATTTTTTGCATTCCTGACAAAGGAGAGCACACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCG TCTCCCGTTCCCTTTGTGCACATCTTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGAT TGTTCGGGTGTGCAATGTCTGAGTGAACCTGTATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGAT TTTGTAACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTATTAAATACAAA ACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGTTAAAACCCCTAT AGCCACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAGGGATCAACCAGCTAAGAAAAG ATTTTAATCAAGTTGAATTGAGGGGATTAATATGAAAACTTATGACCTCTTCCTTTAGGAGGGAGTTAT CTAAAAGAAATGTCTATTAAGGTGATATATTTAAAAATATTTTTGGGTGTTCCTGGCAGTTTAAAAAAA TTGGTTGGAGAATTTAGGTTTTTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAA CAGCTGAATTATCTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAA TCTTATTAGGGAGAAAATTCAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTTCATATT GCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTCTGCAAAAATATTTATAAAACTTC TCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTTTCAATAAAGCATTTATAAATTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005611.4
Synonyms	P130; Rb2
Summary	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.[UniProtKB/Swiss-Prot Function]
Locus ID	5934
MW	52.4

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