AMPK beta 1 (PRKAB1) (NM_006253) Human 3' UTR Clone

Specifications

Product Data
Product Name	AMPK beta 1 (PRKAB1) (NM_006253) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AMPK; HAMPKb
ACCN	NM_006253
Insert Size	1324 bp
Sequence Data	Insert Sequence (showhide) >SC213854 3’UTR clone of NM_006253 The sequence shown below is from the reference sequence of NM_006253. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCACCACCTTGTTATACAAGCCCATATGAAGAGCTGGGGGCGGATGGTGGCCCAGGAGACAGCACACC ACCAGGCTCCACACGTGCATGCTTTCCCCAAGAGGGAATGGACTGTACATTGCTCATTTCACACTCTTC AGAAGACATTTCATACCTGCCCTGGTCCTGCTTGAAGGTTTGTCCAGGCAGAGCAGCTCCTGCAGCGCC TCGGTCTGTGACAGTCCTCCTAGCACCCCCATGGCTTTGAGCCTCGGGGACTCATCAAGTCCAAGAAAA GAGGGAGGGGTGGCAGAGGATCTGCAGCCCTGGCCCCGCGGTGCATGAGGCTGGGTGCAGTTCTAAACC TACATTCTCGATTTTTCTTAAGCCAAAAATGAATGCTAACTCCTTTGCCAGTAAAATTCTGGGAAACAG GGACTGAGGCCACACATCATTTCCAGTCATCTGTGTGTTTTTAAGGCCAGCCACTTGTCCCTGTTGAGG CCTGGCTATGGAACTAAATACAGTGTTGGTCTTGCCTGTCCTTCAAAATCAACAACAGATTGTCTCTCG GCTCCAGGGAGGTGTCATTTCTATAGAAATTAGAAGCTTTCTGATTTCTAGATGAGGTTTTACAATTGT TTCTTACAGTCATGTGCACTAAGTACTCTTTTTGTAAGCAGAGGTGGCTGGCTCTGCAGCCTTAAGGCC ATTTTTTAAGTCACCACGTCTAGAAGTCACATGAACTCTGCTCAGCAATAATCTGTTCTCAGAACAGAC TTTTCAACCTGCTGCCGGATTTCTCCATTCAGCTGGATGATCCTCAGGACTGACCAGTTAGCTGGCAGG TTGTCCAGCTTTTTATTCCAGTCATAATAGGTGACAGTGTTAACCGTGAAAACTTGAGAGGCACTCTGC CCTCTTCCCTATAAAATCACACAGCGTGATTTTACAAGGTCCCGTGGCACCTTGCTCAGGACCTCTGCC CCTAGTTAGCAAGACTGCAGCAGTTGCTGTTGCTTATTCTGAAAGGAATGTAGAACTTGACAGCAGCCT TCTGAGTCTGGGTCAGGAAGATGTCCTTTGGACCAAAGCAGACTTCTTTATACGCAGCTCAGTTTCCCG GGAGTCGCCACAGATGTACCCACTAGCCCAGGTTGCTGTGAGTCAGCGGAAGCTCCCGTTATGCCCTTT GCTCCTGGTGGGAGAGGGAGGAGTGAGCTCCCTGGGTTCCAGTATTTACTTGGTATACCTGAGTTTGGG GGTACCCTTTTTTGTGACTTTTCAAAACAGTGAATTACTGTCACCTTGATGGACAAGTTTCAATAAAAC TTTGTAAAAATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006253.5
Synonyms	AMPK; HAMPKb
Summary	The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Locus ID	5564
MW	48.9

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