PXR (NR1I2) (NM_022002) Human 3' UTR Clone

Specifications

Product Data
Product Name	PXR (NR1I2) (NM_022002) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
ACCN	NM_022002
Insert Size	1305 bp
Sequence Data	Insert Sequence (showhide) >SC213811 3’UTR clone of NM_022002 The sequence shown below is from the reference sequence of NM_022002. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGGAGTTGTTCGGCATCACAGGTAGCTGAGCGGCTGCCCTTGGGTGACACCTCCGAGAGGCAGCCAGA CCCAGAGCCCTCTGAGCCGCCACTCCCGGGCCAAGACAGATGGACACTGCCAAGAGCCGACAATGCCCT GCTGGCCTGTCTCCCTAGGGAATTCCTGCTATGACAGCTGGCTAGCATTCCTCAGGAAGGACATGGGTG CCCCCCACCCCCAGTTCAGTCTGTAGGGAGTGAAGCCACAGACTCTTACGTGGAGAGTGCACTGACCTG TAGGTCAGGACCATCAGAGAGGCAAGGTTGCCCTTTCCTTTTAAAAGGCCCTGTGGTCTGGGGAGAAAT CCCTCAGATCCCACTAAAGTGTCAAGGTGTGGAAGGGACCAAGCGACCAAGGATGGGCCATCTGGGGTC TATGCCCACATACCCACGTTTGTTCGCTTCCTGAGTCTTTTCATTGCTACCTCTAATAGTCCTGTCTCC CACTTCCCACTCGTTCCCCTCCTCTTCCGAGCTGCTTTGTGGGCTCCAGGCCTGTACTCATCGGCAGGC GCATGAGTATCTGTGGGAGTCCTCTAGAGAGATGAGAAGCCAGGAGGCCTGCACCAAATGTCAGAAGCT TGGCATGACCTCATTCCGGCCACATCATTCTGTGTCTCTGCATCCATTTGAACACATTATTAAGCACCG ATAATAGGTAGCCTGCTGTGGGGTATACAGCATTGACTCAGATATAGATCCTGAGCTCACAGAGTTTAT AGTTAAAAAAACAAACAGAAACACAAACGATTTGGATCAAAAGGAGAAATGATAAGTGACAAAAGCAGC ACAAGGAATTTCCCTGTGTGGATGCTGAGCTGTGATGGCGGGCACTGGGTACCCAAGTGAAGGTTCCCA AGGACATGAGTCTGTAGGAGCAAGGGCACAAACTGCAGCTGTGAGTGCGTGTGTGTGATTTGGTGTAGG TAGGTCTGTTTGCCACTTGATGGGGCCTGGGTTTGTTCCTGGGGCTGGAATGCTGGGTATGCTCTGTGA CAAGGCTACGCTGACAATCAGTTAAACACACCGGAGAAGAACCATTTACATGCACCTTATATTTCTGTG TACACATCTATTCTCAAAGCTAAAGGGTATGAAAGTGCCTGCCTTGTTTATAGCCACTTGTGAGTAAAA ATTTTTTTGCATTTTCACAAATTATACTTTATATAAGGCATTCCACACCTAAGAACTAGTTTTGGGAAA TGTAGCCCTGGGTTTAATGTCAAATCAAGGCAAAAGGAATTAAATAATGTACTTTTGGCTAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022002.3
Synonyms	BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Summary	This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Locus ID	8856
MW	48.2

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