KDM6B (NM_001080424) Human 3' UTR Clone

Specifications

Product Data
Product Name	KDM6B (NM_001080424) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	JMJD3; NEDCFSA
ACCN	NM_001080424
Insert Size	1336 bp
Sequence Data	Insert Sequence (showhide) >SC213659 3’UTR clone of NM_001080424 The sequence shown below is from the reference sequence of NM_001080424. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCCAGGCCCCAGCCAGCACGTCGCGATGAGGCCGGACGCCCCGCCCGCCTGCCTGCCCGCGCAAGGCG CCGCGGGGCCACCAGCACATGCCTGGGCTGGACCTAGGTCCCGCCTGTGGCCGAGAAGGGGGTCGGGCC CAGCCCTTCCACCCCATTGGCAGCTCCCCTCACTTAATTTATTAAGAAAAACTTTTTTTTTTTTTTTAG CAAATATGAGGAAAAAAGGAAAAAAAATGGGAGACGGGGGAGGGGGCTGGCAGCCCCTCGCCCACCAGC GCCTCCCCTCACCGACTTTGGCCTTTTTAGCAACAGACACAAGGACCAGGCTCCGGCGGCGGCGGGGGT CACATACGGGTTCCCTCACCCTGCCAGCCGCCCGCCCGCCCGGCGCAGATGCACGCGGCTCGTGTATGT ACATAGACGTTACGGCAGCCGAGGTTTTTAATGAGATTCTTTCTATGGGCTTTACCCCTCCCCCGGAAC CTCCTTTTTTACTTCCAATGCTAGCTGTGACCCCTGTACATGTCTCTTTATTCACTTGGTTATGATTTG TATTTTTTGTTCTTTTCTTGTTTTTTTGTTTTTAATTTATAACAGTCCCACTCACCTCTATTTATTCAT TTTTGGGAAAACCCGACCTCCCACACCCCCAAGCCATCCTGCCCGCCCCTCCAGGGACCGCCCGTCGCC GGGCTCTCCCCGCGCCCCAGTGTGTGTCCGGGCCCGGCCCGACCGTCTCCACCCGTCCGCCCGCGGCTC CAGCCGGGTTCTCATGGTGCTCAAACCCGCTCCCCTCCCCTACGTCCTGCACTTTCTCGGACCAGTCCC CCCACTCCCGACCCGACCCCAGCCCCACCTGAGGGTGAGCAACTCCTGTACTGTAGGGGAAGAAGTGGG AACTGAAATGGTATTTTGTAAAAAAAATAAATAAAATAAAAAAATTAAAGGTTTTAAAGAAAGAACTAT GAGGAAAAGGAACCCCGTCCTTCCCAGCCCCGGCCAACTTTAAAAAACACAGACCTTCACCCCCACCCC CTTTTCTTTTTAAGTGTGAAACAACCCAGGGCCAGGGCCTCACTGGGGCAGGGACACCCCGGGGTGAGT TTCTCTGGGGCTTTATTTTCGTTTTGTTGGTTGTTTTTTCTCCACGCTGGGGCTGCGGAGGGGTGGGGG GTTTACAGTCCCGCACCCTCGCACTGCACTGTCTCTCTGCCCCAGGGGCAGAGGGGTCTTCCCAACCCT ACCCCTATTTTCGGTGATTTTTGTGTGAGAATATTAATATTAAAAATAAACGGAGAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001080424.2
Synonyms	JMJD3; NEDCFSA
Summary	The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Locus ID	23135
MW	49.4

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