PLAT (NM_033011) Human 3' UTR Clone

Specifications

Product Data
Product Name	PLAT (NM_033011) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	T-PA; TPA
ACCN	NM_033011
Insert Size	1305 bp
Sequence Data	Insert Sequence (showhide) >SC213631 3’UTR clone of NM_033011 The sequence shown below is from the reference sequence of NM_033011. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACTGGATTCGTGACAACATGCGACCGTGACCAGGAACACCCGACTCCTCAAAAGCAAATGAGATCCCG CCTCTTCTTCTTCAGAAGACACTGCAAAGGCGCAGTGCTTCTCTACAGACTTCTCCAGACCCACCACAC CGCAGAAGCGGGACGAGACCCTACAGGAGAGGGAAGAGTGCATTTTCCCAGATACTTCCCATTTTGGAA GTTTTCAGGACTTGGTCTGATTTCAGGATACTCTGTCAGATGGGAAGACATGAATGCACACTAGCCTCT CCAGGAATGCCTCCTCCCTGGGCAGAAAGTGGCCATGCCACCCTGTTTTCAGCTAAAGCCCAACCTCCT GACCTGTCACCGTGAGCAGCTTTGGAAACAGGACCACAAAAATGAAAGCATGTCTCAATAGTAAAAGAT AACAAGATCTTTCAGGAAAGACGGATTGCATTAGAAATAGACAGTATATTTATAGTCACAAGAGCCCAG CAGGGCCTCAAAGTTGGGGCAGGCTGGCTGGCCCGTCATGTTCCTCAAAAGCACCCTTGACGTCAAGTC TCCTTCCCCTTTCCCCACTCCCTGGCTCTCAGAAGGTATTCCTTTTGTGTACAGTGTGTAAAGTGTAAA TCCTTTTTCTTTATAAACTTTAGAGTAGCATGAGAGAATTGTATCATTTGAACAACTAGGCTTCAGCAT ATTTATAGCAATCCATGTTAGTTTTTACTTTCTGTTGCCACAACCCTGTTTTATACTGTACTTAATAAA TTCAGATATATTTTTCACAGTTTTTCCAAAATCAGAGTGGAATGGTTTTGTTATAGATGCTGTATCCCA CTCTTTATTCATGTTCACATTTTAAAATCATTTGGAATTCTGCTTCACTCGCTTAACATATACACAACA CCTGTAACATACAAGGCAATGGGCTAGGTGCTCCAGACCGGGAAAAGGAGGGACAGGAATGCTTGGTCT GATGGGCTAATATGGCATTTAGAGAAGTACCAAGGTACAGTGGAGCCGGTCACAAAAGGGCAGACTTGT AGTAGAATTCAGTTGCAAGAGGGATTGGGGAATCTTAAGGAAAAAATAGAATCTTAAGGAAAAAATAAC TGGGTGAGACGTGGACTGTGGACAGGTGTGGAAAAGGCACTCTCCATGGAGGTATGAATATGTAGAGGG CCAAGAGAGGGGAGTACAGGGAGAAATGAGTTGAGCTTGTCTGAAGTGAACTTCAGGAAGAGGAACATA GGCTGGAATTTAGATTATGGGGGCTCTGAACACCAAACTGAGTTTGGACTTAATTGACTTCTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_033011.4
Synonyms	T-PA; TPA
Summary	This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Locus ID	5327
MW	49.9

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