AIF (AIFM1) (NM_001130847) Human 3' UTR Clone

Specifications

Product Data
Product Name	AIF (AIFM1) (NM_001130847) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AIF; AUNX1; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8; SEMDHL
ACCN	NM_001130847
Insert Size	1281 bp
Sequence Data	Insert Sequence (showhide) >SC213553 3' UTR clone of NM_001130847 The sequence shown below is from the reference sequence of NM_001130847. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC CTGTGCTCTTGGCAGAAAGGATATATGAAATCAGGGCATCTTTTCAGGAGGATGCTTCCTATTCAGAGGT TGCAAAGCACTTATGTAAGCCTTAGGTGACTGCATGGGTGGAAGTGCACAGAGTTCACCATCTGAAGCTT AATCTGGGGCCAGCAGTTCTGATACCTGTTGTATTTGCGTTACAAATGAACTTGAGCACCGAGGCCCTCA TGCCCACTGTCCTCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTTCCCCGAGAAAGGAAATATGGGAA AGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGACGAGAGGGGGTTAAGGTGATGCC CAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTTATCAAGCTGAAAGACGGCAGGAAG GTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTGGAGCCCAATGTTGAGTTGGCCAAGACTGGTGGCC TGGAAATAGACTCAGATTTTGGTGGCTTCCGGGTAAATGCAGAGCTACAAGCACGCTCTAACATCTGGGT GGCAGGAGATGCTGCATGCTTCTACGATATAAAGTTGGGAAGGAGGCGGGTAGAGCACCATGATCACGCT GTTGTGAGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAAGCCGTACTGGCATCAGTCAATGT TCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTTGTGGACAGTAGTTTGCCCACAGT TGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCCACAGAGCAGTCAGGAACTGGTATC CGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAAATTACTATTCCTCCCAGCACCCCGGCAGTTCCAC AGGCTCCCGTCCAGGGGGAGGACTACGGCAAAGGTGTCATCTTCTACCTCAGGGACAAAGTGGTCGTGGG GATTGTGCTATGGAACATCTTTAACCGAATGCCAATAGCAAGGAAGATCATTAAGGACGGTGAGCAGCAT GAAGATCTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTGAAGCCCCACAGTGGAATTGGCAA ACCCACTGCAGCCCCTGAGAGGAGGTCGAATGGGTAAAGGAGCATTTTTTTATTCAGCAGACTTTCTCTG TGTATGAGTGTGAATGATCAAGTCCTTTGTGAATATTTTCAACTATGTAGGTAAATTCTTAATGTTCACA TAGTGAAATAAATTCTGATTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001130847.1
Synonyms	AIF; AUNX1; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8; SEMDHL
Summary	This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
Locus ID	9131

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