TXK (NM_003328) Human 3' UTR Clone

Specifications

Product Data
Product Name	TXK (NM_003328) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BTKL; PSCTK5; PTK4; RLK; TKL
ACCN	NM_003328
Insert Size	1274 bp
Sequence Data	Insert Sequence (showhide) >SC213453 3’UTR clone of NM_003328 The sequence shown below is from the reference sequence of NM_003328. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCTGTCACAGAGATTGCGGAAACCTGGTGACCGGAAACAGAATGCCAACCCAAAGAGTCATCTTGCAAA ACTGTCATTTATTGTGAATATCTTCACCATATGGGGTCACTTATGGTGAATATCTTTCTTCAGAGTTGC TGACTCTTGAAAACAGTGCAAAGATCACAGTTTTTAAAAGTTTTAAAAATTTAAGAATATTCACACAAT CGTTTTTCTATGTGTGAGAGGGATTTGCACACTCTTATTTTTCTGTAAAATATTTCACATCCCAAATGT GAAGAAGTGAAAAAGACTTCGCAGCAGTCTTCATTGTGGTGCTCTTCATGATCATAGCCCCAGGAACCC TTGAGGTTCTTCTTCACAAGGCTGAGAGTGCTTCCTTCTTGAAGACGAGTGACATTCATCACTTCAGTG ATCCATGCATAGAATATGAAAATAAATTCTTCCAACTCATGGGATAAAGGGGACTCCCTTGAAGAATTT CATGTTTTTGGGCTGTATAGCTCTTTACAGAAAATGCACCTTTATAAATCACATGAATGTTAGTATTCT GGAAATGTCTTTTGTTAATATAATCTTCCCATGTTATTTAACAAATTGTTTTTGCACATATCTGATTAT ATTGAAAGCAGTTTTTTGCATTCGAGTTTTAAACACTGTTATAAAATGTAGCCAAAGCTCACCTTTGAA CAGATCCCGGTGACATTCTATTTCCAGGAAAATCCGGAACCTGATTTTAGTTCTGTGATTTTACACTTT TTACATGTGAGATTGGACAGTTTCAGAGGCCTTATTTTGTCATACTAAGTGTCTCCTGTAATTTTCAGG AAGATGATTTGTTCTTTCCAGAAGAGGAGACAAAAGCAAGATAGCCAAATGTGACATCAAGCTCCATTG TTTCGGAAATCCAGGATTTTGAATTCGAGATGAAACAACCAGCAATCACAGTTAAATCTTAACTTTGCC TGCACTCTTTGTAGGAATGATCAGAAATTTATCTTTATCATTCTGAGTGCTTCAGGAGTACAATAGGAA GAAAGATACTGGAGAAAGCACTAATGTAATCACCATGAAGTCTGACAACAGGAGCCCATTATTTGCGTA CTGTCCCACCCTGTATCATGGTTCTCTGGGAACAAGCTTTATGATTCTCATTAGAGTTTATTTGTTGAT TGTCAGTAGTTGCGACTTTTAAATTATATTTCCCCCACTCAAAGAATGGTATCTTTATATATCAATGAC ATTCAATAAATGTGTATTATTTCTAATGAGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003328.3
Synonyms	BTKL; PSCTK5; PTK4; RLK; TKL
Summary	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.[UniProtKB/Swiss-Prot Function]
Locus ID	7294
MW	50.1

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.