DCAMKL2 (DCLK2) (NM_001040260) Human 3' UTR Clone

Specifications

Product Data
Product Name	DCAMKL2 (DCLK2) (NM_001040260) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2
ACCN	NM_001040260
Insert Size	1221 bp
Sequence Data	Insert Sequence (showhide) >SC213211 3’UTR clone of NM_001040260 The sequence shown below is from the reference sequence of NM_001040260. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCAGGAACCTGGCGCCGCCACCGAGACTGAGCCTCCTGCAGACGGGCGAAGCCGCCTGCTGCAGCCCAG GAAGCCAGCCCTCTGCTCGGCCTCGCCGGCCTCCCTGCTGCAGGCCTCCCTCTCTTCACCGCCTGCGCC TGAGTTCGCGGGTCCTCCGCAGGCCGCCTGGGAACCGGAGCCTGGCGTGCCGGAGCCTGGCCTGGTGCT CTGGGCTCTGCCTTCTGGTTCCTGGAGGCATCAAAGGCTGCATCCGTTCTGCCAACAGCTGTTCGGAGA GACTCGTTCCAGATCATCCCGTCATTTTCAGTTTGTTGGACATTTTACAGCTTCACCAGGAGAATGTGC AACTTTATTCCAGCATTCGATGCATTTTTATAGAAACACTTTGGAAACACTTTGGATGAACCAAGGCCT TTTCCTTATTTAAGTAGACTCAGAACACTCCCTTTCTTTTCTTTTCTCTCTCTCTCTCTCTTTTTTTTT TACGAAAGACTTAGAATTGCATTTGTCCTTTTGTGGGTGTCCTGTGAGAGGTGATATGGGGGCTAAGAG GACTGGCTTTCTAATAGAAGAAGTGAGCGCCTGAGAGGACAATTTGGTCATTGGACACGGATTGCAGGC TTTGAGAAGCGCTCAGAGGCCCAGGGCGGCGGGCTCAGCCATTCGGCTTGGGGCACCAGGCTCCCCAGA GACAATGCTCAGTATTCATTCATACACAGACGATGGAAGAAGCCACTTCTTCCCTGGGCGGTGTGGGTT TCCCCCAGCTCTTCCCACACGTGTGTTAGGAAATGCCCGTGAACTTGCCCTCTGGGCTTTTTAATGAGA GGCTTGGCGCATGCGGCACCCAGCGGCTGCTTCCCTGCAAGCCAGCGACTTGCCGAGCAGAATGAGCTC TGCTCCTGAGCCCCGGTAGCTGCTTCCTCATCTGCATTTCATCTGGAGCAGGGCAGGTAACCACAGGAG GAGGCATGCCCGAGGCAGCCAGGACTGGGCGGGAAGGTGCTCCCTGGATATACTCTGTGAACCTTCTGG AAGGCTGCTGGCAGTTTTTCCTTTTTGTCCACCACCCTGCTCTTTTTAATAATTGTACATAATCCGTGT ATTTGTTTTACCTGCTCATCTTCTAAACTGGCGAGCCCTATAGTTCGTTCTCATTGTTAGATTTTGCCT TTTACAAGTGTCCCCAACCTGCAATAAACTTTTCCCTCTTGAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001040260.4
Synonyms	CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2
Summary	This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Locus ID	166614
MW	45.1

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