SHIP (INPP5D) (NM_001017915) Human 3' UTR Clone

Specifications

Product Data
Product Name	SHIP (INPP5D) (NM_001017915) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
ACCN	NM_001017915
Insert Size	1225 bp
Sequence Data	Insert Sequence (showhide) >SC213170 3’UTR clone of NM_001017915 The sequence shown below is from the reference sequence of NM_001017915. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGGCCTCTAGGCAGGACTGCCATGCAGTGAAGCCCTCAGTGAGCTGCCACTGAGTCGGGAGCCCAGAGG AACGGCGTGAAGCCACTGGACCCTCTCCCGGGACCTCCTGCTGGCTCCTCCTGCCCAGCTTCCTATGCA AGGCTTTGTGTTTTCAGGAAAGGGCCTAGCTTCTGTGTGGCCCACAGAGTTCACTGCCTGTGAGACTTA GCACCAAGTGCTGAGGCTGGAAGAAAAACGCACACCAGACGGGCAACAAACAGTCTGGGTCCCCAGCTC GCTCTTGGTACTTGGGACCCCAGTGCCTCGTTGAGGGCGCCATTCTGAAGAAAGGAACTGCAGCGCCGA TTTGAGGGTGGAGATATAGATAATAATAATATTAATAATAATAATGGCCACATGGATCGAACACTCATG ATGTGCCAAGTGCTGTGCTAAGTGCTTTACGAACATTCGTCATATCAGGATGACCTCGAGAGCTGAGGC TCTAGCCACCTAAAACCACGTGCCCAAACCCACCAGTTTAAAACGGTGTGTGTTCGGAGGGGTGAAAGC ATTAAGAAGCCCAGTGCCCTCCTGGAGTGAGACAAGGGCTCGGCCTTAAGGAGCTGAAGAGTCTGGGTA GCTTGTTTAGGGTACAAGAAGCCTGTTCTGTCCAGCTTCAGTGACACAAGCTGCTTTAGCTAAAGTCCC GCGGGTTCCGGCATGGCTAGGCTGAGAGCAGGGATCTACCTGGCTTCTCAGTTCTTTGGTTGGAAGGAG CAGGAAATCAGCTCCTATTCTCCAGTGGAGAGATCTGGCCTCAGCTTGGGCTAGAGATGCCAAGGCCTG TGCCAGGTTCCCTGTGCCCTCCTCGAGGTGGGCAGCCATCACCAGCCACAGTTAAGCCAAGCCCCCCAA CATGTATTCCATCGTGCTGGTAGAAGAGTCTTTGCTGTTGCTCCCGAAAGCCGTGCTCTCCAGCCTGGC TGCCAGGGAGGGTGGGCCTCTTGGTTCCAGGCTCTTGAAATAGTGCAGCCTTTTCTTCCTATCTCTGTG GCTTTCAGCTCTGCTTCCTTGGTTATTAGGAGAATAGATGGGTGATGTCTTTCCTTATGTTGCTTTTTC AACATAGCAGAATTAATGTAGGGAGCTAAATCCAGTGGTGTGTGTGAATGCAGAAGGGAATGCACCCCA CATTCCCATGATGGAAGTCTGCGTAACCAATAAATTGTGCCTTTCTCACTCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001017915.3
Synonyms	hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Summary	This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Locus ID	3635
MW	44.5

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