LAPTM4B (NM_018407) Human 3' UTR Clone

Specifications

Product Data
Product Name	LAPTM4B (NM_018407) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LAPTM4beta; LC27
ACCN	NM_018407
Insert Size	1569 bp
Sequence Data	Insert Sequence (showhide) >SC212679 3’UTR clone of NM_018407 The sequence shown below is from the reference sequence of NM_018407. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTT TGCAGACATCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCT GAAATGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTGGAA CACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCC CTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAA GTTGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTTTT TCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTT CTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTG AAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAA GCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGG TGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTC TTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTTCAAGG AGGTCATCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACATGGA AAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTT TAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTG AATTGCAAGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAA TGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTT GTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGG AGTAGGCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGT TAAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGAGTGAAAACTAATACACT ATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTT CTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAGT AGAAAAAGGTGTAGCCGGCATACAAATGTTATCTACAGTGTATTTTTAGAT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_018407.6
Synonyms	LAPTM4beta; LC27
Summary	Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).[UniProtKB/Swiss-Prot Function]
Locus ID	55353
MW	59.7

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