PPM1D (NM_003620) Human 3' UTR Clone

Specifications

Product Data
Product Name	PPM1D (NM_003620) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	IDDGIP; JDVS; PP2C-DELTA; WIP1
ACCN	NM_003620
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC212597 3’UTR clone of NM_003620 The sequence shown below is from the reference sequence of NM_003620. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAACACAGGAAAACTGTTTGTGTTTGCTGAAATGCATCTGGGAAATGAGGTTTTTCCAAACTTAGGATA TAAGAGGGCTTTTTAAATTTGGTGCCGATGTTGAACTTTTTTTAAGGGGAGAAAATTAAAAGAAATATA CAGTTTGACTTTTTGGAATTCAGCAGTTTTATCCTGGCCTTGTACTTGCTTGTATTGTAAATGTGGATT TTGTAGATGTTAGGGTATAAGTTGCTGTAAAATTTGTGTAAATTTGTATCCACACAAATTCAGTCTCTG AATACACAGTATTCAGAGTCTCTGATACACAGTAATTGTGACAATAGGGCTAAATGTTTAAAGAAATCA AAAGAATCTATTAGATTTTAGAAAAACATTTAAACTTTTTAAAATACTTATTAAAAAATTTGTATAAGC CACTTGTCTTGAAAACTGTGCAACTTTTTAAAGTAAATTATTAAGCAGACTGGAAAAGTGATGTATTTT CATAGTGACCTGTGTTTCACTTAATGTTTCTTAGAGCCAAGTGTCTTTTAAACATTATTTTTTATTTCT GATTTCATAATTCAGAACTAAATTTTTCATAGAAGTGTTGAGCCATGCTACAGTTAGTCTTGTCCCAAT TAAAATACTATGCAGTATCTCTTACATCAGTAGCATTTTTCTAAAACCTTAGTCATCAGATATGCTTAC TAAATCTTCAGCATAGAAGGAAGTGTGTTTGCCTAAAACAATCTAAAACAATTCCCTTCTTTTTCATCC CAGACCAATGGCATTATTAGGTCTTAAAGTAGTTACTCCCTTCTCGTGTTTGCTTAAAATATGTGAAGT TTTCCTTGCTATTTCAATAACAGATGGTGCTGCTAATTCCCAACATTTCTTAAATTATTTTATATCATA CAGTTTTCATTGATTATATGGGTATATATTCATCTAATAAATCAGTGAACTGTTCCTCATGTTGCTGAA TTTGTAGTTGTTGGTTTATTTTAATGGTATGTACAAGTTGAGTATCCCTTATCCAAAATGCTTGGGACC AGAAGTGTTTCAGATTTTTTAAAATTTTGGAATATTTGCTTTATACTGAGCTTTTGAGTGTTCCCAATC TGAAATTCAAAATGCTCTAATGAGCATTTCCTTTGAGCATCATGCCTGCTCTGAAAAAGTTTCTGATTC TGGAGCATTTTGGATTTTGGATTTTCAGATTAGGGATGCTTAACCTGGATTAACATTCTGTTGTGCCAT GATCATGCTTTACAGTGAGTGTATTTTATTTATTTATTATTTTGTTTGTTTGTTTGAGATGGAGTCTCA CTCTGTCATCCAGGCTAGAGTGCAGTGGCGTGATCTCGGCTGACTGCAACCTCTGCCTCCCGGGTTCAA GTGATTCTCCTGCCTCAATCTCTCTCCCCAGAAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTA ATTTTTTTTTTTTTTTTTGAGATGGAGTCTAGCTCTGTCATCCAGGCTGGAGTGCAGTGGTGTGATCTC GGCTCCCTGCAACCTCTGCCTTCTGGGTTCCTGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGAT TACAGGCACGCGCCACTGTGCCCAGCCAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACATGTCAGT CATGCTGGTCTTGATCTCCTGACCTCGTGATCCACCCGCCTCGACCTCCCAAAGTACTGGGATTACAGG CGTGAGCCACCGCATCCGGCCTGAGTTTTATGCTTTCAATGTATTTCTTACATTTCAGTTCAAGTGATT TTCATGTCTCAGCCTCCTGAGTAGCTGGAACTACAGGTGCGTGCCACCATGCCTGGCTAAGTTTTGTAT TTTTAGTAGAGATGGGTTTTCATCATGTTGGCCAAGATGGTCTTGATCTCTTGACCTCATGATCCACCA GCCTAGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCAACTATGCCATTATT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003620.4
Synonyms	IDDGIP; JDVS; PP2C-DELTA; WIP1
Summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Locus ID	8493
MW	76.5

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