ULK3 (NM_001099436) Human 3' UTR Clone

Specifications

Product Data
Product Name	ULK3 (NM_001099436) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_001099436
Insert Size	1140 bp
Sequence Data	Insert Sequence (showhide) >SC212493 3’UTR clone of NM_001099436 The sequence shown below is from the reference sequence of NM_001099436. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCTGTTCGTAGCTCTTGCACCCTTCAGTGACCCTAGAAGAATGATTGGACAGATGTGAGCCATCTGGAG CAGAGGGGCACTAACCCAGGCTGACGCCAAGAATGAAGTGGCCCACTGCAGCCCTGGCGAGCAGGCTTC TTGGATGGACAGTGCTGAGACCCCCATATCCCAGAGTCCCCAGCCTCCCTCAGGTTACTCTGCACCCCA CAGATGGTTTGATGGCTGTGCTGTATACTGGAGGGGAGGGCAGGACTCTGGGAGAACAGCACTTCTTTC ATGAGACCTTTGTTACTCGGTGGTTACTGGGTCCTGTGCCTGTCCGTTTTGGGGCATGCAGCCCTCTAT CATTTTTGGCTCCGAGAAGAGGGCAAGGGGCCCCCGCAGGGTACTTCTGTGCTTGCCCTCGCCCTGCCA GCAGGCAGCTGTGCCCCTGGCCTGCCCTTCCCGGGACCCCTTATTCCAACTCAGCTCCTCTTTGCACTG GAATGGGGCACTCCAACACCCCTCAGGGACCACCCTCCCCACAGTATGCACTCAGCCCCACAGAACCCA CCAGTCTTTCTGGGAACTCACACCTGCCCGCCATCTTGGTACTTTAGGTTAATCCCTCAAGCATGAAAG CTGGATCTTTTGGGGTTTAAGAAGCCCAAGCCTTGTTCCTGCCCTGGCCTAGGGAGCACTCAGGAGGGT TCCTTGGTCCTCATCTCTCCCACCTCCGTTCCCTCTGGGCCCCACACTAGCCACAGCGCGGGCCTTGTG CTGGAGTTTGAGCCTGGGACAGGGAGAGGGAGGCTTGGAGACAGTCTGACCCAGTGCCCTCTAGGCCAC CCACTTCTAGGCCTGCCCTGCCGCCGTGGAGCCCTGGGCAAGCTCTTTCCCCTTTCTGGGCCTGGGTCT CCCCATCTCTTCAATGGGGCTGATACCTTCACAGCCCACAGCATGGGCACTTATGAGGACAAAGTGAAT TTAACCTGGAAAAGAATGTATTTGAGAGTTTCTTTTAAATAATCAGCGGGTGTTGGTGATTTGTAGCCC TTCTGCCCTTAAATGCTTCCTTGGGCAAGAGCTGTCTGTCCTCCCTGCAGGAGGCTGAGTGTAAAGAGT ATCATTCATTGTTTCTCTATTAAATTATTTTCTCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001099436.4
Summary	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.[UniProtKB/Swiss-Prot Function]
Locus ID	25989
MW	41.3

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