Activin Receptor Type IA (ACVR1) (NM_001105) Human 3' UTR Clone

Specifications

Product Data
Product Name	Activin Receptor Type IA (ACVR1) (NM_001105) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
ACCN	NM_001105
Insert Size	1115 bp
Sequence Data	Insert Sequence (showhide) >SC212415 3’UTR clone of NM_001105 The sequence shown below is from the reference sequence of NM_001105. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCCTCGACAAATTGAAAACTGACTGTTGACATTTTCATAGTGTCAAGAAGGAAGATTTGACGTTGTTG TCATTGTCCAGCTGGGACCTAATGCTGGCCTGACTGGTTGTCAGAATGGAATCCATCTGTCTCCCTCCC CAAATGGCTGCTTTGACAAGGCAGACGTCGTACCCAGCCATGTGTTGGGGAGACATCAAAACCACCCTA ACCTCGCTCGATGACTGTGAACTGGGCATTTCACGAACTGTTCACACTGCAGAGACTAATGTTGGACAG ACACTGTTGCAAAGGTAGGGACTGGAGGAACACAGAGAAATCCTAAAAGAGATCTGGGCATTAAGTCAG TGGCTTTGCATAGCTTTCACAAGTCTCCTAGACACTCCCCACGGGAAACTCAAGGAGGTGGTGAATTTT TAATCAGCAATATTGCCTGTGCTTCTCTTCTTTATTGCACTAGGAATTCTTTGCATTCCTTACTTGCAC TGTTACTCTTAATTTTAAAGACCCAACTTGCCAAAATGTTGGCTGCGTACTCCACTGGTCTGTCTTTGG ATAATAGGAATTCAATTTGGCAAAACAAAATGTAATGTCAGACTTTGCTGCATTTTACACATGTGCTGA TGTTTACAATGATGCCGAACATTAGGAATTGTTTATACACAACTTTGCAAATTATTTATTACTTGTGCA CTTAGTAGTTTTTACAAAACTGCTTTGTGCATATGTTAAAGCTTATTTTTATGTGGTCTTATGATTTTA TTACAGAAATGTTTTTAACACTATACTCTAAAATGGACATTTTCTTTTATTATCAGTTAAAATCACATT TTAAGTGCTTCACATTTGTATGTGTGTAGACTGTAACTTTTTTTCAGTTCATATGCAGAACGTATTTAG CCATTACCCACGTGACACCACCGAATATATTACTGATTTAGAAGCAAAGATTTCAGTAGAATTTTAGTC CTGAACGCTACGGGGAAAATGCATTTTCTTCAGAATTATCCATTACGTGCATTTAAACTCTGCCAGAAA AAAATAACTATTTTGTTTTAATCTACTTTTTGTATTTAGTAGTTATTTGTATAAATTAAATAAACTGTT TTCAAGTCAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001105.5
Synonyms	ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Summary	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Locus ID	90
MW	42.8

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