Hyaluronan synthase 2 (HAS2) (NM_005328) Human 3' UTR Clone

Specifications

Product Data
Product Name	Hyaluronan synthase 2 (HAS2) (NM_005328) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_005328
Insert Size	1123 bp
Sequence Data	Insert Sequence (showhide) >SC212271 3' UTR clone of NM_005328 The sequence shown below is from the reference sequence of NM_005328. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC AGGCGGAAGAAGGGACAACAATATGACATGGTGCTTGATGTATGATCTTCCATGTTTTGACGTTTGCAGT CACACACAACACCTTAGTTCCTCTAGGGGCTGTACAGTATTGTGGCATCAGATAATGCCACCAAAGGAGA CATATCACTGCTGCTGGGACTTGAACAAAGACATTTATATGGGTTTATTTTCATTCTGCCAAAGTAAAAC AATACATCAACAAGAAGAAACTCAGATTTAACCTGTTATTTCTATGAAAATGGGATGAATTCTTTGTTTA TGCACTTTTTCCTTACTGTGCATCCGCCTGAAAGTGTTTTGCCCTATATACCTCACTAGCCATGCTTTAT GTGGGTTATCATGGAAGAAAAGGATTTTGGAAACTCAAGGAAAAGTTCTTTCAACCTATACAACCTAACT TATGGACTGTTTTGATAGATGATAATTTTTTTTTTTTAGGAAGGATTTTCTTTTTAACTTTACCAAATGA AATGCCAAAGGAAGTTTTAAAGGCCGTTGGCTGTGCTGTATTTTGATATAATTGTACTGTGTTTTTAAAT TTTGTATGCCAATCTTAAAGACAAATTTTGCATATTCTCTATTTTACTTTTCTGCCAAAATAAACCTGTT CTTCCTTTTTTAAAATAAAATAAGTTCTTAAAAAATTTATACTTAAAAAATCCTGCCCAAAATGTGAAGC TTGGTTGACTGATGTTCATGATAGAAAGAATAAAATGTTTCTCTCTCTCTACCTTTTAAAATTGAATAGT TTATTTCTGTGAAAGAAGTATTTAAACTTTCAATATTTTAACTTTTTGTTTTTATTTCTTTTAGAAAAGG CCAATATACCTATCACACTTTGGAAGTAAAAATACACACTTTCGTGTGTACCTAAAAAAAAAATCGTTGA AAATCAAGGCCAAAGGTAGTGCAATTTTTTCATTAAGATTTAAAAAAAAGGGAATGATAGTCTTTGAAAG AAAACAGTAGGCATCCAGCACTGGACAAAACATGGGTATCAAAGATGAATAATCTTTGGAGATTCTGGCA GTGTTTTCCCAGAACAAGTCAAGTGGAAAGTGGAGAAATTATCTGTATAATTTTGGACACATACAATGCA GTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005328.2
Summary	Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
Locus ID	3037

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