DIP13B (APPL2) (NM_018171) Human 3' UTR Clone

Specifications

Product Data
Product Name	DIP13B (APPL2) (NM_018171) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DIP13B
ACCN	NM_018171
Insert Size	1044 bp
Sequence Data	Insert Sequence (showhide) >SC212262 3’UTR clone of NM_018171 The sequence shown below is from the reference sequence of NM_018171. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAACATAGAGGCGCAGAATCCGAAGCATAACTCACTTGCGCCTGTGGGGGAAGAGCAAACAGGAAGGAG AGCTACCTCCTAAGGGTTTTAACGTCTCTGACATACAGGCACACTGACCTGATTTCCGAAGGCTGACAA TCGTTTGTGGAATGTAATCTTGATGCCTTGATACTGAGACTTGGGAGGGAAACTAAGAAATGGTTGACA GCGTTCCCACCCATCTACAATGTTATTTTAGGTGCTTTGTGGTAAGTCTTTTTTCTTAGATTGCGCTAA AATTTCTTAGATTGTTCAGCGCTCAGAACAAAAGTTTGAAAAATGCATTGTTCATATGAATGTCATCTC TTTTCAGTTTCCAGTATCCTTTTTAAAAAATGGCAAAAGCCTAGATTTACAATTTGATGAACACTAAAT ATTTCTTATTAATATAATCTATTTTTGTATTTTACTTAATGAGCTTTAAGTGCCTGTCGTTCTGAAAAT TGTGTATTTATAATTCAGCTTATCTCATAATTGGACCTAATAGCATTTCTTTGTGCAGTTAGGTGATGA GCACTGCTTTGAGGCCCAAGCACTAGTAGAGATGCGCGATACAGGTCTAGTTTCGGTAACTGTTCCAGA CATCAAGCAATAAAAAAATGAATACCACAAAAGATGTTTGATTTTACAGTGGAGCCTTACTGAACCAGC ATTCAGAAGTTTAAGGTCCTCCTAGGTATGAGTATTTTTAGTAGTGGATCACTGTGGACAGGGTGCAGC TCTACCAGTTCCTGTTTCTTCTGAGCCAGACCCTCTTCAGGGAAGGGACCAATTAATTTTAAAACTCAC TTGAAGCACAGCTGGTCATGGGGCTTGGTATAAAGTTCCTATTTCCACCCTGATACTTCCAATTCCTGG AACCCCAGCCCACTCCCCCATCCCTCCTCCCTATCAAACTAGTATAATGATTTTGAATCGGTACAGTGT GTTTAACTGTAACTAAGTTCAACAGACTATTATTATCTTTGTAATAAATTAACCTAGCAATAAAAAATA TTCTGTTTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_018171.5
Synonyms	DIP13B
Summary	The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Locus ID	55198
MW	39.8

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