RASA1 (NM_002890) Human 3' UTR Clone

Specifications

Product Data
Product Name	RASA1 (NM_002890) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASGAP
ACCN	NM_002890
Insert Size	1063 bp
Sequence Data	Insert Sequence (showhide) >SC212043 3’UTR clone of NM_002890 The sequence shown below is from the reference sequence of NM_002890. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGTATACAAAAACCAATGATGTCAGGTAGCAGCCTTCGCCCCAGTGTTCTGCATGGATTCAGCATGTC CAACATGGTAATTCACTTCAGTTTAATGTCTCCTTTGCTCTTGCCAAAAAATAGCACACTTTTCCACAT TCCAGTGATGTGTGAGCTATGCAAACAAAATCCAAGATTCTGCTGGTGAATAACTATGCCAGCAACCTT GTAAGCTATCTGTGCAGGATATTTGCACTATTTCCACATGGAATCAATCTTTAACAACCTCTGAGCCTT GGTGTACAGACCACCTTTCACAAAACGAAATGCTATGACTGTATCTTGATATCTCGAACTTTCAAAATA TATTTTCAGTACACCCAGTTGCCAAAGTTTTGCTGTCTCTTAGAGAAAGAACTATGAAATCAACTGACA AGAAACACATTCTTATTGACAATTGTGTATAACTGGATTGCAGACTGTTCTTACTGTAACTACTTCCTG ATTAGGAATATGACCATTTGACTGTTCAATGATTATTTGTATTTACAGTTTCCAGAGTTTGTCATTATA ATAGGAACAATCTTTGCTGTATACTTTTAAAAAATACTCTGCTATTTCTCTTGCTGGAACTGTTGAAAG AAAATATATAGAATGATCTATTGCTCATCAGCTTTATTTTTTAAACATACGACTTATTTTGTTGAAATT GTCAAAGACTGTATTTAGATCTCATAATGCTTTGTTAAATGTTTACAAGTAAATAGTTTGAATTCAGTA AATATTATTGGTTGTTGTATTGATCAATGCATGTTACCCATTCAACCATTTTATAGACTACCAATTTCT TTTATGTTAACTAGAATGCTTTTGTTAAAAGTTATTTGTTCATTATTTGTGCTACCCCTTTGATTATGC AGACAACCTCATCAGCTGCCTAACTTATCCATCTTTGAACTTCTGACTACTTGTTGTATCTGCTGGATA TTTAGTTCAACTGTATAGTTTTATTTACTTCTGTATGTGTATTTTTGTGAAGTATTCACAAAGGTTAAG TTAAAATAAAACCAAGGGATATCTTGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002890.3
Synonyms	CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASGAP
Summary	The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Locus ID	5921
MW	41.5

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