Polycystin 1 (PKD1) (NM_000296) Human 3' UTR Clone

Specifications

Product Data
Product Name	Polycystin 1 (PKD1) (NM_000296) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PBP; Pc-1; PC1; TRPP1
ACCN	NM_000296
Insert Size	1049 bp
Sequence Data	Insert Sequence (showhide) >SC211839 3’UTR clone of NM_000296 The sequence shown below is from the reference sequence of NM_000296. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGAACAAGGTCCACCCCAGCAGCACTTAGTCCTCCTTCCTGGCGGGGGTGGGCCGTGGAGTCGGAGTG GACACCGCTCAGTATTACTTTCTGCCGCTGTCAAGGCCGAGGGCCAGGCAGAATGGCTGCACGTAGGTT CCCCAGAGAGCAGGCAGGGGCATCTGTCTGTCTGTGGGCTTCAGCACTTTAAAGAGGCTGTGTGGCCAA CCAGGACCCAGGGTCCCCTCCCCAGCTCCCTTGGGAAGGACACAGCAGTATTGGACGGTTTCTAGCCTC TGAGATGCTAATTTATTTCCCCGAGTCCTCAGGTACAGCGGGCTGTGCCCGGCCCCACCCCCTGGGCAG ATGTCCCCCACTGCTAAGGCTGCTGGCTTCAGGGAGGGTTAGCCTGCACCGCCGCCACCCTGCCCCTAA GTTATTACCTCTCCAGTTCCTACCGTACTCCCTGCACCGTCTCACTGTGTGTCTCGTGTCAGTAATTTA TATGGTGTTAAAATGTGTATATTTTTGTATGTCACTATTTTCACTAGGGCTGAGGGGCCTGCGCCCAGA GCTGGCCTCCCCCAACACCTGCTGCGCTTGGTAGGTGTGGTGGCGTTATGGCAGCCCGGCTGCTGCTTG GATGCGAGCTTGGCCTTGGGCCGGTGCTGGGGGCACAGCTGTCTGCCAGGCACTCTCATCACCCCAGAG GCCTTGTCATCCTCCCTTGCCCCAGGCCAGGTAGCAAGAGAGCAGCGCCCAGGCCTGCTGGCATCAGGT CTGGGCAAGTAGCAGGACTAGGCATGTCAGAGGACCCCAGGGTGGTTAGAGGAAAAGACTCCTCCTGGG GGCTGGCTCCCAGGGTGGAGGAAGGTGACTGTGTGTGTGTGTGTGTGCGCGCGCGCACGCGCGAGTGTG CTGTATGGCCCAGGCAGCCTCAAGGCCCTCGGAGCTGGCTGTGCCTGCTTCTGTGTACCACTTCTGTGG GCATGGCCGCTTCTAGAGCCTCGACACCCCCCCAACCCCCGCACCAAGCAGACAAAGTCAATAAAAGAG CTGTCTGACTGCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000296.4
Synonyms	PBP; Pc-1; PC1; TRPP1
Summary	This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]
Locus ID	5310
MW	37.1

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