ICAD (DFFA) (NM_004401) Human 3' UTR Clone

Specifications

Product Data
Product Name	ICAD (DFFA) (NM_004401) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DFF-45; DFF1; ICAD
ACCN	NM_004401
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC211368 3’UTR clone of NM_004401 The sequence shown below is from the reference sequence of NM_004401. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTAAGCGAGCCAGACAGGATCCCACATAGCAGCAGCGGGAAGTGTGCCAAGGAAGCTCTGTGGCGTTG TGTTATTGGTAGACACCCTCAGCCTCATCATTTGACTACCTATGTACTACTCTACCCCCTGCCTTAGAG CACCTTCCAGAGAAGCTATTCCAGGTCTCAACATACGCCGTTCCACCAATTTTTTTTTTAGCCCCACCA GCTTCAGGACTTCTGCCAATTTTGAATGATATAGCTGCACCAACAATATCCCGCCTCCTCTAATTACAT ATGATGTTCTCTGTTCAAAAGTAATTGGCAGTGATTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCA GCACTGGGAGGCCGAGGGGGGCGGATCGTGAAGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAA ACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGCCATGGTGGCGGGCGCCTGTAATCCCAGCTA CTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCAGAGCTTGCAGTGAGCTGAGATTGCGC CACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAGTAATTGGC AGTGACTATGGGCGCACTGCCTAACATTTAGCCCTGCCCCATATGGAACATGTTAAAAAAAAAAAAAGC CAGGCCGAGCGTGTTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAG GTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACGTGTTTTTACTAAAAGTACAAAAAACTAGC TGGGCGTGGTGGCAGGAGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCG GGGAGGCAGAAGTTGCAGTGAGCCGAGATTATGCCACTGTACTCCAGCCTGGGTGACAGAGTGACACTC TGTCTCAAAAAAAAAAAAAAAAAGGACAGGCACGACAGTGGCTCACACCTTTGATCCCAGCACTTTGGA GGCCGATGCAGGCGGATCACATGAGGTCAGGAGTTCAAGACCAACCTGGCCAATATGGTGAAACCCCGT CTCTACTAAAAATACAAAAATTAGCTGGGCATGATGGCGGGTGCCTGTAATCCCAGCTACTCGGTAGGC AGAGGTTGCAGTGAGCTGAGAGCGCACCACTGCACTCCAGCCTGGGTGACAGAGCTAGACTCCGTATCT CAAGAAAAAAAAAAAGTTTTGTTTTGTTTTTTTGAGACAGAGTCTCACTCTGTCACCTAGTCTGGAGTG CAGTGGCACATTCTCGGCTCACTGCAACCCCCACCTCCCAGGTTCAAGCGATTCTCCTGTTTCAGCCTC CTGAGCAGCTGGGATTACAGGCACGTGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGG GTTTTGTCACATTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCA AAGTGCTGGGATTACAGGTGTGAGCCACCACCCCTGGCCAGAAAAAAAAGCTTTTAAATAAAGTAATTG TCAGCTTAGGCAACATAGCAAGACCCTGTCTCTACAAAAAAAAAATTTAAGTTAGCCAGGCATGGTGGC ACTGACCTATAATCCTAGCTACTCTGGAGGCTAAGGCGAGAGTATCACTTGAGCCCAGGAGCTCAAGGC TGATCATGCCACCATACTCCAGCCTGGATGATAGAGTAAGACCCTACTTTTTTTTTTTTTTTTTTAAAA AGGTAACCATCAAGGGCAATGAAAAGAAATGGTCGTATTTCCAATTCATTATCCTTATTCTGAAGATAG TACGGCAGAATTTTAAGCAGAGATAGTGGTGAAGATGGTGACATTATAGAGTGTTGACTATGGCCACAA TCTTGTTTCTCCAGTTAATGAATTTTTTTATGTGTTTGTTTAAAGATACATATTAAGCTTGTAGACCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004401.3
Synonyms	DFF-45; DFF1; ICAD
Summary	Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Locus ID	1676
MW	75.6

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