Glutathione Peroxidase 3 (GPX3) (NM_002084) Human 3' UTR Clone

Specifications

Product Data
Product Name	Glutathione Peroxidase 3 (GPX3) (NM_002084) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GPx-P; GSHPx-3; GSHPx-P
ACCN	NM_002084
Insert Size	888 bp
Sequence Data	Insert Sequence (showhide) >SC210760 3’UTR clone of NM_002084 The sequence shown below is from the reference sequence of NM_002084. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGGCAGCCCTGGGGGTCAAGAGGAAGTAACTGAAGGCCGTCTCATCCCATGTCCACCATGTAGGGGAG GGACTTTGTTCAGGAAGAAATCCGTGTCTCCAACCACACTATCTACCCATCACAGACCCCTTTCCTATC ACTCAAGGCCCCAGCCTGGCACAAATGGATGCATACAGTTCTGTGTACTGCCAGGCATGTGGGTGTGGG TGCATGTGGGTGTTTACACACATGCCTACAGGTATGCGTGATTGTGTGTGTGTGCATGGGTGTACAGCC ACGTGTCTACCTATGTGTCTTTCTGGGAATGTGTACCATCTGTGTGCCTGCAGCTGTGTAGTGCTGGAC AGTGACAACCCTTTCTCTCCAGTTCTCCACTCCAATGATAATAGTTCACTTACACCTAAACCCAAAGGA AAAACCAGCTCTAGGTCCAATTGTTCTGCTCTAACTGATACCTCAACCTTGGGGCCAGCATCTCCCACT GCCTCCAAATATTAGTAACTATGACTGACGTCCCCAGAAGTTTCTGGGTCTACCACACTCCCCAACCCC CCACTCCTACTTCCTGAAGGGCCCTCCCAAGGCTACATCCCCACCCCACAGTTCTCCCTGAGAGAGATC AACCTCCCTGAGATCAACCAAGGCAGATGTGACAGCAAGGGCCACGGACCCCATGGCAGGGGTGGCGTC TTCATGAGGGAGGGGCCCAAAGCCCTTGTGGGCGGACCTCCCCTGAGCCTGTCTGAGGGGCCAGCCCTT AGTGCATTCAGGCTAAGGCCCCTGGGCAGGGATGCCACCCCTGCTCCTTCGGAGGACGTGCCCTCACCC CTCACTGGTCCACTGGCTTGAGACTCACCCCGTCTGCCCAGTAAAAGCCTTTCTGCAGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002084.5
Synonyms	GPx-P; GSHPx-3; GSHPx-P
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Locus ID	2878
MW	31

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