CACNA1A (NM_001127222) Human 3' UTR Clone

CAT#: SC210646

3' UTR clone of calcium channel voltage-dependent P/Q type alpha 1A subunit (CACNA1A) transcript variant 4 for miRNA target validation



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CNY 4,845.00


货期*
3周

规格
    • 10 ug

Product images

经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name CACNA1A (NM_001127222) Human 3' UTR Clone
Vector pMirTarget
Synonyms APCA; BI; CACNL1A4; CAV2.1; DEE42; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6
ACCN NM_001127222
Insert Size 901 bp
Sequence Data
>SC210646 3’UTR clone of NM_001127222
The sequence shown below is from the reference sequence of NM_001127222. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
TACAGCGAGAGTGACGATGATTGGTGCTAAGCCCGGGCGAGGTGGCGCCCGCCCGGCCCCCCACGCACC
CCACGCACACACCCCACCCGAGGAGCCGCGCAGAGGCCGCGGGGGCCCAGCACAGAGGGCCCGGGAGAG
GGCCAGCCGGGAGACCCCAGACTCTGGAGAGGCCAGGGCTGGGCCACAAGGGTGTCCCGCAGAGACCCT
CGGCCAAAAGAGACCCTCCTGGGCAGCCACGGCGCCCCCCAACCAGCCCCGATCCCCCCACCCACGACA
GGGGCTCTCGGGTGGGAGGCAGGGAGCAGACAAACCACACAGCCAAGGGATTTGAATTAACTCAGCCAT
TTTTGGAGAACTTTGGGGAACATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACATTTTTAAAAGAAAA
AACGGGGAGAAAAAAATAGCTTCTATTGATGAGTTTTATCATCTCAATTGAATCTTTCCTTTCCCTGAT
GAAGACAGCTGGTGGCCGAGTGCGGCAAAGAAGCCAGAAGGAACCAGAATCCCAGTGCCCTACACCCAC
CACCAGACACACTCACACCCACACACGTTCTCAGACACACACAAGAGTGCTTGCCGGTTATACCAAACC
CTACTATTACTGCCTGCAGAAATCAATTTAAAAAAATAATAATAACAATAAACAATTTTAAAAAGGACA
AAAAAATTAATGATTGAGAAAAGAGGCATTTTTTTCTGACATTTGGTCCTGCTTGAAACAACAAAAGAA
GAAGAAAAACCCACCATCACCACCGATTCCTTTGCTTCTTTTTTCCTTTTTTCCTACCTTGTTTGAAAA
CCGTGGGCTTGGGACTGTGAATTATTGCATGACATTCAAAAAGAAAAAAAAAATAAAAAAAAGTTGAAT
CAAA
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_001127222.2
Synonyms APCA; BI; CACNL1A4; CAV2.1; DEE42; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6
Summary Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Locus ID 773
MW 34.7
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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