CACNA1A (NM_001127222) Human 3' UTR Clone

Specifications

Product Data
Product Name	CACNA1A (NM_001127222) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	APCA; BI; CACNL1A4; CAV2.1; DEE42; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6
ACCN	NM_001127222
Insert Size	901 bp
Sequence Data	Insert Sequence (showhide) >SC210646 3’UTR clone of NM_001127222 The sequence shown below is from the reference sequence of NM_001127222. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACAGCGAGAGTGACGATGATTGGTGCTAAGCCCGGGCGAGGTGGCGCCCGCCCGGCCCCCCACGCACC CCACGCACACACCCCACCCGAGGAGCCGCGCAGAGGCCGCGGGGGCCCAGCACAGAGGGCCCGGGAGAG GGCCAGCCGGGAGACCCCAGACTCTGGAGAGGCCAGGGCTGGGCCACAAGGGTGTCCCGCAGAGACCCT CGGCCAAAAGAGACCCTCCTGGGCAGCCACGGCGCCCCCCAACCAGCCCCGATCCCCCCACCCACGACA GGGGCTCTCGGGTGGGAGGCAGGGAGCAGACAAACCACACAGCCAAGGGATTTGAATTAACTCAGCCAT TTTTGGAGAACTTTGGGGAACATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACATTTTTAAAAGAAAA AACGGGGAGAAAAAAATAGCTTCTATTGATGAGTTTTATCATCTCAATTGAATCTTTCCTTTCCCTGAT GAAGACAGCTGGTGGCCGAGTGCGGCAAAGAAGCCAGAAGGAACCAGAATCCCAGTGCCCTACACCCAC CACCAGACACACTCACACCCACACACGTTCTCAGACACACACAAGAGTGCTTGCCGGTTATACCAAACC CTACTATTACTGCCTGCAGAAATCAATTTAAAAAAATAATAATAACAATAAACAATTTTAAAAAGGACA AAAAAATTAATGATTGAGAAAAGAGGCATTTTTTTCTGACATTTGGTCCTGCTTGAAACAACAAAAGAA GAAGAAAAACCCACCATCACCACCGATTCCTTTGCTTCTTTTTTCCTTTTTTCCTACCTTGTTTGAAAA CCGTGGGCTTGGGACTGTGAATTATTGCATGACATTCAAAAAGAAAAAAAAAATAAAAAAAAGTTGAAT CAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001127222.2
Synonyms	APCA; BI; CACNL1A4; CAV2.1; DEE42; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6
Summary	Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Locus ID	773
MW	34.7

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