P5CS (ALDH18A1) (NM_001017423) Human 3' UTR Clone

Specifications

Product Data
Product Name	P5CS (ALDH18A1) (NM_001017423) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ADCL3; ARCL3A; GSAS; P5CS; PYCS; SPG9; SPG9A; SPG9B
ACCN	NM_001017423
Insert Size	851 bp
Sequence Data	Insert Sequence (showhide) >SC210365 3’UTR clone of NM_001017423 The sequence shown below is from the reference sequence of NM_001017423. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTCCCTATTCCTCAGAGAAACACCAACTGAAAAGAGCCAGGAAAACCCGGGAATTTTCCAAAAGGTCTT CACGTTAAACTTGTCTTATCTCAGGAGAGAGCCCGCTCTTGTCTCCCAGTTCCTGGTAGGGTCTGCCTG TTGGAAAGTGTACCTGGATGCTTCTGGGCTCCGTTTGGCAATAGCAGTCTTGGCTGATGTGCACAGTCT GGCTCCCAGCTCACCCTTTTTTTTTAAAGTAAGAAAATAGTTGCTACCGATAGGGACTTTGCCAAGTCC AATTATCTTCTAGGATTGAAAGGTGCATTTTCCCCATAAAAAAGGCGAGGAAAACCCATGGCTGCTTTG TGTCACCTCAGTGACTTACAGTCCCCCTTGGCATTTAGTTGGTACTAGAGCCAGTCATCCTTAACAAAT CTTTTCACATTTTATTTCTTTCACATGTAGTCATCTTCAAAAAGGAAAGATTTGGAATTTTAGAAAAGG GGCAACTCTTCTTTTTAGCATTCTCATCAGAAAGTCACAAAAATCGATGGAATCATTTCCACTGGGAAG ATTGACCTTTTGTATTTATTTGTGGGGTAAATTAATAAGCATTCCAGATGCTTGCAGCTTCCTGCATCC AGGAGATGCTGTGTTCCCCGTGATGCAGCTGGAACCCAAGCTGCAGCAGGAGATGCAAGTTTCAGGATG TTCCCCACTGAGCTGGAGGAATATCTACAGCAGTGATGCTTGAAATTTTTGTATGAATTATTTTGTCGT CCTACCCTTTTCCTCCAAAACAAAAATTAGAGGATTATTTTAATACTTTGGATTCTTCCCCCTTTTTTG AGAAATAAAGTTTTTTATGAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001017423.2
Synonyms	ADCL3; ARCL3A; GSAS; P5CS; PYCS; SPG9; SPG9A; SPG9B
Summary	This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]
Locus ID	5832
MW	32

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