Aspartate beta hydroxylase (ASPH) (NM_001164756) Human 3' UTR Clone

Specifications

Product Data
Product Name	Aspartate beta hydroxylase (ASPH) (NM_001164756) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin
ACCN	NM_001164756
Insert Size	846 bp
Sequence Data	Insert Sequence (showhide) >SC210271 3’UTR clone of NM_001164756 The sequence shown below is from the reference sequence of NM_001164756. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGTGTCATATTGGATTTACATAACCAGTAACCTTGATTCAGGGACTGAAGTCATTGGCTAATGAACACC TGAAGCAGCCTCCTTTTTCTTTTCTTTCCTTGGCTTATGCAGGGCTTAATGTGCAGTGGGGTGGTTGTG ATCTTACCGTGCAAGTCAACCATGTGATCTTGCCCAGTACAGCTACTAGCTAGTCCCTTGCTCGCTCAG CTCCCCCAACTTCTATTGAAGAAAATGGTACTCCTCATTCTTGTAGTCAGCTACAAAGTACACTGAAAA TGATGTTCTTGGTGGTATAATTGGTTTCTGTATCGTTTTGTTTCAACTCATGTATTCACTGAACTAAAT TTGGACACTTAACAGCAAATTGTGTTGTGGTTAACCCTTGATGCTTGTCTTTCTAACACACTATTAATT ATGATGATTCTAATGGATTTCATTATAAAAATATTTCTGGCATGATTTTTAAGTTAAATGCTTCTCTGT TCTTTAACATGACTGATGTATAAAATGATGGTTCTTTACTAAGCTGATATTTTTTATTGTAATTTGTTT AGGTTTGTCAGATAGGTTCATACAAATTTCTATGTAAAATTCTGTGTTAATGGTGCTTTTAAAATAATT TAAAAATAACTCCATGTTTTTGCCTTAGAGTAAGTTAACTTACTGTTTTCAGATAGTAGCATGACATAT TTCTGTCTGTGAAAGCAAAATTTATTTTAAATTTTATTTCCAAATATACATCCAGAGAAAGTAATTTGT ATTTTTTTTAAAGTAGGCATATTACACAAGAGGGAACATGTGAATATGTATCTTAATGTTGTACATATT AAAATTATTCATCCTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001164756.2
Synonyms	AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin
Summary	This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Locus ID	444
MW	33.2

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