LATS1 (NM_004690) Human 3' UTR Clone

Specifications

Product Data
Product Name	LATS1 (NM_004690) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	WARTS; wts
ACCN	NM_004690
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC210118 3’UTR clone of NM_004690 The sequence shown below is from the reference sequence of NM_004690. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATTAAAAATCGCGATCTAGTATATGTTTAACACACTAGTAAATAAATGTAATGAGGATTTGTAAAAGGG CCTGAAATGCGAGGTGTTTTGAGGTTCTGAGAGTAAAATTATGCAAATATGACAGAGCTATATATGTGT GCTCTGTGTACAATATTTTATTTTCCTAAATTATGGGAAATCCTTTTAAAATGTTAATTTATTCCAGCC GTTTAAATCAGTATTTAGAAAAAAATTGTTATAAGGAAAGTAAATTATGAACTGAATATTATAGTCAGT TCTTGGTACTTAAAGTACTTAAAATAAGTAGTGCTTTGTTTAAAAGGAGAAACCTGGTATCTATTTGTA TATATGCTAAATAATTTTAAAATACAAGAGTTTTTGAAATTTTTTTGAAAGACAGTTTTAGTTTTATCT TGCTTTAACCAAATATGAAACATACCCCCTATTTTACAGAGCTCTTTTTTCCCCTCATAACCTTGTTTT TGGTAGAAAATAAGCTAGAGAAATTAAGCCATCGTGTTGGTGAGTGTTCCTAGGCTAATGATAATCTGT ATAATTCACATCCTGAAACTAAGGAATACAGGGTTGAAAAAATATTAATATGTTTGTCAGAAGGAAAAA TAATGCATTTATCTTCCCCCCCACCCCCCGCCCCATGGAATATTTAATCTATTTAATCTTCTTGCATTT ATTTCTCAAGAATTACTGGCTTTAAAAGAAGCCAAAGCACTACTAGCTTTTTTTCCATATTGGTATTTT TGATGCTGCTTCCAATTTTAAAAGGGAACAAAGCTGCCATAAATCGAAATGTTCAATACTAAAAGCTAA AATATTTCTCACCATCCTAAGCAGATAATTATTTTAATTTTCATATACTTTTCCTGTATAGTAACTATT TTGATTATATCATCAATGTTACCTGTTTCCTCTTTCAGAACAGTGCTGCATATACAGATTGTTATTGGC AAAGGAAAATCTGGCTATCTGGCAATATTTTACCTAAGCGCAGATTAATTGGTGAAAAAATTAACTCTT AAGATGGCCATTAATAATTAGGAAAGTTTACAGAGTGGTCTTAGTAGAAAATTCAAGTCCTCCTAATTT ATTTAAGGTTCAATAATGCGTTCAACATGCCTGTTATGTATAACGCTTAGGTTCTAAGGAAGATTAAGG TTTCATACCAAAATACATGTAGCTTATCTTTTAGGAAGGGGAAAAAGGCTCCATTTTGACCATAGTAAA ATTTGTGTTGTGTTTTATTTCCTTTTCTTAAGCTCCACTGATAAGGGATTGTTTTTATCAAAAGTTACT ATTTGTAGATTGGAGGCATAATTTTAGTGATTTTCATACTTTTAGCTTTCTTCGCATAAAAGCTAATTG AAACCGTATATGTAGTAAAATTAAAGGCAGAGCTGTTGCAGTTGAATTGGAGAGTTAGGGCAAAGAACA CTTATTAGCCCACACTTCCCACCTTTCTACAGGTGGTCCTTTCAGAGCTCAGCCTGAAAACCCACTACT GTGTTATCGTGCGTCTTTTGGGGTTAGTGGTTCTTTTGAGAATCTGAAGGAAGCTGTGGACTCTTCCTA GAAAAAAAAACCACACATACACATACAATGTTGCATGCAGTTTCAAGGGATTTTGGACATATTGAAACC TATCACAGGCTGTAGGTTATGGACCTCTGTGCCATGAGAAAATTGATACATTAAACTAAGAACTTTGTT TTTAACTTACCAATCACTACTCAGCACATCTTATATAAGCTGATAATTTGTGATGGAAAAGGTCTGTAG CATGTGATATAAGGTGACCTTATGAATGCCTCTCTTGCTGGTACATTAAGTTGTTTTAATATATCATTT GGAGGGGACTGAAATGTTAGGCTCATTACAAGCTTGATACAGAAATATTTCTGAAGGATTTCTAATCAG AATTGTAAAACAATGTGCTATCATGAAATCGCAGTCTTCACCTCATGGTTCATGGAACATTTGGTTAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004690.4
Synonyms	WARTS; wts
Summary	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Locus ID	9113
MW	77.4

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