KCTD6 (NM_001128214) Human 3' UTR Clone

Specifications

Product Data
Product Name	KCTD6 (NM_001128214) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	KCASH3
ACCN	NM_001128214
Insert Size	754 bp
Sequence Data	Insert Sequence (showhide) >SC209376 3’UTR clone of NM_001128214 The sequence shown below is from the reference sequence of NM_001128214. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGTAGGCTAGCCCGGAAGACAGACGACTGATCTCCGACCCTGCCACAGGTTCCTGGAAAGACTCTCCAG GAAATGGAAGATACTGATTTTTTTTTTTAAATCACAGTGTGAGATATTTTTTTTCTTTTAAATAGTTGT ATTTATTTGAAGGCAGTGAGGACCAGAAGGAAGTTTTGTGCTTTGGCAGACTCCTCCATGTTTTGTTCC CTTCCCCCTGAGTATGCATGTGCCTGTTCAGAGTCTCCAGATACCTTTTTTATAAAAAGAAGTCTGAAA ATCATTATGGTATATAATCTACCCTTAACAGAGCTTTTCTTATTACAGTGCTAAAATGATTTCTGATAA AATGGTCCCTAACTCAACTAGAAGGCTAAAAATACAAGAATGAAAGAATAAGCAGAGTACTCATGATGC CTTTGAGAAAAATCAAAACATCATGTAGGGTGACCTAGTTTCCAAACCAATAAATAAGTAGTATTGTAA TATTAAAGGAAAACTGTTCCAATCATTTAAAAGTACTTATTAAGTACTGCTTTTTACAGTTATGACAAC TGTTTCTTTCTATGCATATAAATCAAGGAACCAAATATCTGTAGCCATGGAAATGTCTGACTAGAAATA TTTATATTGAATTCTGAATACAAAATGTCCCTGTGGTAGAAAACTTACTCTTTATGCCTGGTGCAGTAT AATTCCCAAGTGTACTGTCTACCAGAAAAAAAAAACAAAACTAATAAAAAATGAAATATGAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001128214.2
Synonyms	KCASH3
Summary	Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).[UniProtKB/Swiss-Prot Function]
Locus ID	200845
MW	29.2

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