MCM4 (NM_005914) Human 3' UTR Clone

Specifications

Product Data
Product Name	MCM4 (NM_005914) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CDC21; CDC54; hCdc21; IMD54; NKCD; NKGCD; P1-CDC21
ACCN	NM_005914
Insert Size	1412 bp
Sequence Data	Insert Sequence (showhide) >SC209348 3’UTR clone of NM_005914 The sequence shown below is from the reference sequence of NM_005914. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGACTGGGAAGACCGTGCGCTTGCTCTGAAGCCTTGTGAGCAAGGAAGGCTCCCTGCATGTCCTGCTT GCTGCACGCCACATGGGTGTGGTCTGCATCTCAGTTGGCCGCCATCAGTGTAAATAGAGCTTAAAGTCA TGGTTTGGCTGCATAAAAATTTTCTAACTTGGGTTCAATATTTGTAGTGAAGTATCTGTTTTCATTTTT TTCACGTTATAAATAAAAATACTATGCTGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTG GGAGGCCAATGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTAGCCAAGATGGTGAAACCCCG TCTCTAGTAAAGATAACAAAAAATTAGCTGGGCTTGATGGCATGCGCCTGTAATCCCAGCTACTCGGGA GGTTGAGGCAGGAGAATCGCTTAAACCCAGGCGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCA CTCCAGCCTCAGCAATAGAGTGAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAACCTGCCAATTTTCAA ACATACCGTAGAGATTATTTTCAGGTGCCATTTTATAGTATAGCAGCAGGGCTTTTACTCTGTGTATGC ACAGATGCAGTCTGGGGCATGGTTTGTGTGCTGGACTTTCTCATGGCCATCATCAGTATGCTTATGGAT TTGATGACAGGCATAGCCTGGGCATATCACCTCATTGGTAAAGGGCTAGAGCCTTTCTTTTTTATGGCA CTTCTTTTTTTGAGATAGGGTCTTACTCTGTCACCCTGGCTAGAGTACACTGGTACAATCACGGCTCAA TGTAGGCTTAACCTCCTGGGCTCAGGTGTATGTCACTATGCCCGGCTACTTTTTGTATTTTTTGGTAGA GACGGCTTCGCCACGTTGCCCAGGCTGCAAGCGATATGCCTAGGCTCAAGCGATCTGCCCACCTCAACT TCCGGAAGTGCTGAGATTACAGGTGTGAGCCACTGCACCCAGCCTTTGTTTTATTTTTTATTTTTTGAG AGGTATGATTCTTTCTAGAGATTTTTTCTCATGGCTACTATTAGATCAGGAATGGGTGATTGGAGATTA TTAGATTCTAGGTTAACTTCTACCACTTTACCCTAATACATAAAACTTTTTCCTAAATAAATGATGGAA GGAATAATACTTGGTTACCTGGCATTATTTTTCAGTAAGAAAAAAGCTTTACTAACCACTACATTTATG GAAATTTGTAGGGGTAAGTATTTTATAGGTCATAAAAAACACCATAATATAACGAATCTCATTTTCTTT AAATGTGAATTAAATCCTAACAGTCATCTTTATAAAATGACCATAGGCTAAAATCTTACGTGTAAGTAC TACTACAATAAATAATTTCTGAAACCTTTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005914.4
Synonyms	CDC21; CDC54; hCdc21; IMD54; NKCD; NKGCD; P1-CDC21
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Locus ID	4173
MW	52.7

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