ZNF207 (NM_003457) Human 3' UTR Clone

Specifications

Product Data
Product Name	ZNF207 (NM_003457) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BuGZ; hBuGZ
ACCN	NM_003457
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC209066 3’UTR clone of NM_003457 The sequence shown below is from the reference sequence of NM_003457. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTGTAATGTCGCAAGGTGGCCGTTACTGATCTTACTTCATCCAGTCTAATAGGTTTGGAGATTAAACC TTTTCTCAACTTGTGCTGTTTATATAGCCAAGCTTCCGTCAATAAGGCTTCATTGTGACTTTAACAAAC ATTATCTTCCCACATACCAGGAACTATTGGACATTTATTTTACATGGGAAAAATTATTTGGAATAATAA AGCAGGAACTTTTCCTGAAGTTGCAATTTATACTGTATGGCTTCTTTTTCATGTTTCATCTAGGTTTTT AGAAGTGAAGTATAGTAAATTTGGTTCGTTAAATTGTGAAGGCGCTGGAATTACATGAACATACCACCC TAGTAAAGGCAAGTTCTGTAAGCTTACATTGCTATTTGTAAAGTTTGCCTTCACAGCATTTCAGATGCT GTTGGACTTCATGTCCCCAACCTAGCTTGGTGAGGGCTGTAACTGTTTCCAAGTACTTGTACATTGGAA GTCTGAATGTGTAACAATATTTAATGTATTTAGAGTTCCTCATGTTGCAGGGTTTAAGAAATCTGACCC ACCAAGGTCATGTGACTTTTCTGTACTGTTAAACTTCATTGTAATAAAATGAGAGAAAAATTTATGCCT TTTTATTCATAACCCAGCTGTGGACCACTGCCTGAAAGGTTTGTACAGATGCATGCCACAGTAGATGTC CACATAATAAAATTCATAGTTACCAATGCAGTTTTGATATATCATTGGATTCTGTCTTTGAGTTGTAGG TTATTTCTTAGCTGCATGTTTTAAACTGAATTTGCATAGAGTTGTATGTTAATGTTTCAGTTAAGAGAA AAACTTAAGATACATGAGTCATTACATAATGGGTATGAAATCTTTATAATCACCCTTCCACCCTCTATG GTGTCAGTACACATCACGTGTCATAGATACTTAAAATGTAAATGTTAACACTTTTCCTTCCTGCTGAGA TGTTTAGAGCCTAGTGCCAGACCCATTCATTTCCTTTTGATTATTTTTGAGACTCAGTACTGCATGGAC CTCAGAAGCTTTTCAGGTGCAAACTTCTAGAAGCTTAGGTGCATGCAGTAATAGCTTCTTGTGCTGTTA ATGGGTTATTATATATTATTCTAAGTGTAATGCTGAGAATCTAAATGTGTCTCTGTTGGGATGGTTAAC AGATGAATTGGCAATTTTTATTATGTTCCTGGAAGATTACATTATTCATTTGAGTACCTTCTGTTATTA AGCCTAGGTAGCCTTACTGTGCAACTTTTTATTTATCCTTGGAAATTTTGAATGTTGTGTTCTTACAGA GAGCTTTTCTGTAGAGATGACTGCTATTCAATATTTTGTGTTGCAACCTCTTAAAATAATAGCTCTTGT TGACCTTTTTGGGATCTGTTTTTCTGATCTTTTGCAGGGTAGTTTTATGATTTTTTAGGCATCAAATAA CCTATGCAAAGTATTAATATAATGAACTCAAGTTGAGTTTTTCTCATTATAAAGTTAAGACTTCTAAGA AAATGGTAACATTTCTTTATAACTTTCCTGTGAAGGTATAGATAAAACACATGAAGTCTGAAGTTGTAT GGAAAAAAGGGCTTTAACTTTGAAGGAAAATATATTGAAAAGTGATTTAGCCATCACAAAAGAGTTCGT ATTTATGTGACAGATGAAAGTCATACCTTTAAGCAAAACATTGCAAGTATTATAAAGCTGAATGCTATT TTAACTCACATTGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCCCTCTGGAAGGCTGAGATGGGA GGATTGCTTGAGTCCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCCATCTGTACAAAACAT TTAAAAATTAGCCAGGCGCGTTAGTGTGTGTCTGTGGTCCCAGCTGCTCAAGAGGCTGAGGAAGGAGGT TCTTCCTCCTTCCGAGGCTGCGGTGAGCTATGTTCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003457.4
Synonyms	BuGZ; hBuGZ
Summary	Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).[UniProtKB/Swiss-Prot Function]
Locus ID	7756
MW	77.6

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