Nicastrin (NCSTN) (NM_015331) Human 3' UTR Clone

Specifications

Product Data
Product Name	Nicastrin (NCSTN) (NM_015331) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ATAG1874
ACCN	NM_015331
Insert Size	708 bp
Sequence Data	Insert Sequence (showhide) >SC208960 3’UTR clone of NM_015331 The sequence shown below is from the reference sequence of NM_015331. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCCGGGAGCCAGGAGCTGTGTCATACTGAGGAGGACCCCAGCTTTTCTTGCCAGCTCAGCAGTTCACT TCCTAGAGCATCTGTCCCACTGGGACACAACCACTAATTTGTCACTGGAACCTCCCTGGGCCTGTCTCA GATTGGGATTAACATAAAAGAGTGGAACTATCCAAAAGAGACAGGGAGAAATAAATAAATTGCCTCCCT TCCTCCGCTCCCCTTTCCCATCACCCCTTCCCCATTTCCTCTTCCTTCTCTACTCATGCCAGATTTTGG GATTACAAATAGAAGCTTCTTGCTCCTGTTTAACTCCCTAGTTACCCACCCTAATTTGCCCTTCAGGAC CCTTCTACTTTTTCCTTCCTGCCCTGTACCTCTCTCTGCTCCTCACCCCCACCCCTGTACCCAGCCACC TTCCTGACTGGGAAGGACATAAAAGGTTTAATGTCAGGGTCAAACTACATTGAGCCCCTGAGGACAGGG GCATCTCTGGGCTGAGCCTACTGTCTCCTTCCCACTGTCCTTTCTCCAGGCCCTCAGATGGCACATTAG GGTGGGCGTGCTGCGGGTGGGTATCCCACCTCCAGCCCACAGTGCTCAGTTGTACTTTTTATTAAGCTG TAATATCTATTTTTGTTTTTGTCTTTTTCCTTTATTCTTTTTGTAAATATATATATAATGAGTTTCATT AAAATAGATTATCCCACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015331.3
Synonyms	ATAG1874
Summary	This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Locus ID	23385
MW	26

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