RNF146 (NM_030963) Human 3' UTR Clone

Specifications

Product Data
Product Name	RNF146 (NM_030963) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_030963
Insert Size	899 bp
Sequence Data	Insert Sequence (showhide) >SC208862 3’UTR clone of NM_030963 The sequence shown below is from the reference sequence of NM_030963. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATGGACAGTGCACAGTAACTGAAGTTTAAATAAAAATGTCTTCAGCTCCATGCTCAAGGTTGAAAGGG TTACCTGTAAATTTCTGCCCACATAACATTATACTCATCCCTAGTAGTGCATTTTGGGAGTTGGGGTGG GAAGGGGTATGGGAAGGATAGACTCATAATTAAAATGTCTAACATGTCTCTGTTGAGAAATTTATTTAA TGTAAGGAACTTGGGTGTTAATAGTTGAGAGCTGTTTAGTAATAACCCAGTTTTCTTGAGGTCTGTTTA CTTTATACTTTTTAAAAACTTCTGTAGTTCTTTTGGCCAGTGTGTTTGTATTATCTGTGCATTAATGGT CCTCATCTGACTCCTGCATTGTGTCTTATTTTTCTGCATGGATTGGCATAAGACCATTACTAAAATTTG GCACCTGTGAGATGTTTGATATTATGAACAGGAAACATAATTTAATGTATGAATAGATGTGAATTTGGG ATTTCAAAATAGATGAATAACAACTATTTTATAGTAAAGTTATTGAAATGGAAATGAAAACAGCCAGTA ACTTATGTTTCAGAATGTTTGTAACACACTTCATGGTGTTCCCATAGGCTTTGCTGTCTAGTCTTATAG TTTGAGGTTTTTTTGGTCTGCATTTTTCTTTTTGATTACAAAATTTATAATTTAATAAATACTAGAGTT TATCAAAAACAGTTTGTCTCTTGTTTGAGGGTGGAAAGGGTGTGGAAACATTTTGACATTTGTGACCAA AGGTCACTTAAAAAGTGGTGGTTTTAATTGGTTGTTTTCAGCTTAATCACCTGCTCAGAAAAGTTTGAT TTTTTTCTTAGAGATTATTTAAACAGAATCTATAGGCAGTGTGTATATAATAAACATGTATGGAAATAA AA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_030963.4
Summary	E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.[UniProtKB/Swiss-Prot Function]
Locus ID	81847
MW	35.2

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