MAML2 (NM_032427) Human 3' UTR Clone

Specifications

Product Data
Product Name	MAML2 (NM_032427) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MAM-3; MAM2; MAM3; MLL-MAML2
ACCN	NM_032427
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC208738 3’UTR clone of NM_032427 The sequence shown below is from the reference sequence of NM_032427. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAA AAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAA CATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAA TCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATT TATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTC CCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTT CCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCA TTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTAT GCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCA CTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAA AATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTT AGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACT TTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGC TTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCAT TTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCAT GTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGA AGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCA ACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGC CACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTT TGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTT GGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTC AGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCA ATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTC TGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAA TATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTC TTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAA ATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACT TAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCT GAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032427.4
Synonyms	MAM-3; MAM2; MAM3; MLL-MAML2
Summary	The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Locus ID	84441
MW	76.4

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