Kininogen 1 (KNG1) (NM_000893) Human 3' UTR Clone

Specifications

Product Data
Product Name	Kininogen 1 (KNG1) (NM_000893) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BDK; BK; HAE6; HMWK; KNG
ACCN	NM_000893
Insert Size	655 bp
Sequence Data	Insert Sequence (showhide) >SC208240 3’UTR clone of NM_000893 The sequence shown below is from the reference sequence of NM_000893. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGCCAGCATCTGAGAGGGAGGTCTCTTGACCAATGGGCAGAATCTTCACTCCAGGCACATAGCCCCAA CCACCTCTGCCAGCAACCTTGAGAGGAAGGACAAGAAGAAAGATGGGATAGAATTTAAATAGAGAAGAA TGCCATTTTATCACTCTGCCTCTGGGTGAAATAAAGATCAGTCTTGATGTTCTAACTCTAATTCACAGT GGTCTCCTTTCAGCCCTACCCATTCTGCAGCAAATTCCAGCTGGTCAGAGAGTCAGTGCTGTGGCTCTG CCATGGAGGCTCATAACCCAACACTGGAACATTCCCTAGCCAAGGCAGAAGTCCTTAGGCGGGACTTCC TTACCACCACGGGTGCTAAAAGAAGAGTTAGTAGGTCATGCTTCTACCAGTAATCTAAGGACTCTCTCC TTCTCTTCTTCCTCTTTCTCCAGATTTCCAAGCCTTAGCTAAGAGTAATTTGGCTTGTTTAGTATTGTT TTCTTATGGTCCAGTTAATTACCAAAAATATTTTTAAAATCATCTCTGTTAATAGAATGTCTACCAACT TCTCACTATCAGAAAATACTCAACCTCCAAACAATTTGAAATTATCTTTCTGATCCAGGTAAAGAAGCA AATTGAAAATCAATAAAGTAAAAAGTGACGGAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000893.4
Synonyms	BDK; BK; HAE6; HMWK; KNG
Summary	This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]
Locus ID	3827
MW	24.3

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