Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (NM_000746) Human 3' UTR Clone

Specifications

Product Data
Product Name	Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (NM_000746) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CHRNA7-2; NACHRA7
ACCN	NM_000746
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC207827 3’UTR clone of NM_000746 The sequence shown below is from the reference sequence of NM_000746. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGGAGGCCGTGTCCAAAGACTTTGCGTAACCACGCCTGGTTCTGTACATGTGGAAAACTCACAGATGG GCAAGGCCTTTGGCTTGGCGAGATTTGGGGGTGCTAATCCAGGACAGCATTACACGCCACAACTCCAGT GTTCCCTTCTGGCTGTCAGTCGTGTTGCTTACGGTTTCTTTGTTACTTTAGGTAGTAGAATCTCAGCAC TTTGTTTCATATTCTCAGATGGGCTGATAGATATCCTTGGCACATCCGTACCATCGGTCAGCAGGGCCA CTGAGTAGTCATTTTGCCCATTAGCCCACTGCCTGGAAAGCCCTTCGGAGAGCTCCCCATGGCTCCTCA CCACCGAGACAGTTGGTTTTGCATGTCTGCATGAAGGTCTACCTGAAAATTCAACATTTGCTTTTTGCT TGTGTACAAACCCAGATTGAAGCTAAAATAAACCAGACTCACTAAATCCTTTCCAATAATTGACTGGTG GAAGGAAAACAAAAAACAAAAACTAAAAACCTCTTAGCTTTTCTGCAATTCAACTTTTTATTTTTATTT TTATTTCTATCAAAGACGGTAGAGAGAAACAGCTTGATGCTGTTTCTACATTAAAAAAAAAAAAAAAAG ACAGACTGTTGGTCTTACTAAGGATGTTTTTACCAGCCTGCCTGACTTCTGCAAACCTACCCTGTCAAG GAGATCAAAGGGACGCAGGTTTCTGTTTATTCTGAACAAGGGCCAGGCCCCGCGGAGTGTCTTTGGTGG ATCCCAGATAACTCCTAGGTGCTGCTCTCAGACACTGAGGAGTTGAGCAAATCTGTTCTATTCTGCAGA ACCCACAGGACAAATAAGAGTTCTACTAGAATTAACAGCCCAAAAGAATAGCTACAGCTAAGTGAAGCC ACTTACGTGGGCTTTAAAAAAATAATGTGTTAGCTGATTCACATGCACTGGAGTTAATTAGTCTTAGAA ATGTGTGCATCCATACAAATGCACAACATAAAGTGAACATATTCCTAGGCCCTTTCTGCCTGTGTCAGG GCCAGGAAGTAGAGGCTGGGAACTCTTCTGGTCCCCAGTATGGCAGGCGCCAGGGAGGGGATGGTGTGG CCCATCCCTTCTCTGGATACCTGGCCAGTGGCAGGCAGCAGGGAGGAGCTGGCCGACCCTCAGTGACTG ACAAGCCAGCAATTCTGAGTTCTGGCCTTTGGGAGTCTGCCTGCTCCAAGCCAGTCCACCCCAGCTGCA GCCCCAAAAGCTGGCTCAAAGTCCTTGGGTGGATTCACTGGAGATGGGCAACTTAAAACAAGAGAAACT TTAATTTTTAAACCTAAGTGATGATACAGCTCTTCCCTTAGATTATCGCCCAGGCTGGAGTGCAGTGGC ATGATCTCAGCTCACTGCAAGCTCCACCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCCCCGA GTAACTGGGAATACAGGCGCCCGCCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATAGGGTT TCATCATGTTAGCCAGGATGGTCTCATTCTTATTCTTTAATGAGATCAGAGGGTAATTCACCAAGAAAG ACCTCTCCTGTTCCATTGTGTCATCCAACAACTGCTCAGAGCTCAAAATTATAGAAGGCTTCTGAGCCC CTAGAGATTTTTAATTTGCTTCTAATCCCTGAGGTGGGAACATCATGAGGGAAGATTTGATTTTCAGAG TTAAATAAATTGTATGTGCTTTTCCAGCCATCTGGCTCACTCATTTCTGGGTAATGCACATGACTTTGT TTGCACTGGAGGAAGATGGAAGCTTGCGTGTGTGCGGTGTGTGTGTGTGTGTAAGTGTGAGGTACCTTG TGTGTGACAAGAGACCTCACTTACGAGAAAGTTGGTGGATCAGGACATTCCAGCCTCAGGCGGCTTGGA GCAGGATCATTCCTCAGCAGGCATTCCTTCCACATGCTATGGATGAACCATGCACAAGATTTTCGGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000746.6
Synonyms	CHRNA7-2; NACHRA7
Summary	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Locus ID	1139
MW	74.5

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