Kininogen 1 (KNG1) (NM_001102416) Human 3' UTR Clone

Specifications

Product Data
Product Name	Kininogen 1 (KNG1) (NM_001102416) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BDK; BK; HAE6; HMWK; KNG
ACCN	NM_001102416
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC207543 3’UTR clone of NM_001102416 The sequence shown below is from the reference sequence of NM_001102416. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TATTTCGATCTCACTGATGGCCTTTCTTAATTTAAGTGGCTATGGGTATTTCTTTCATACTTTATTAAA GTATCAATATCCCTCTCTCCATTGTCCAGATGAAAATATCCTGATATAATGCACCAAAAACCATGCAGC TTCGGAACAGTCTAAAGAGAAGTGGTGAGACTCCCAGTGGAGACACCATCAGTCTCCACGGACTGCATA AAATTGTGTGCCACAATTCTAACTCTTTTCTGAATCTTCTTCCCAAGTTTTCTAAACTAGCACAGTAAA CAGACAAACTAATGTGCCGTATGGCCTGCTGCAATTGGCTTCTCTGATAACAAATATGTACCTTACAAC ATATGTCATGAATTTGCATACAAAGATTCTTGTCATTCTTAATAAACTGTGGCACTTGGTATTTGAATG TGTGTGAAAATAAGGGAAGTCAAGAGATTAAATGCTGAACTTATTAATGGAATAGAAATAATAAGGAGG CTGAGGCTGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCGCT CCAGCCTGGGCATCAGAGCAAGATTCTGTCTCAGAAAAAAAGAAAAAAAAAGAAATAATAAGAAAAACT TCCAGATTTCAAAGTAACAAGAAAGAAGACAGGTTGGCCAAAGGGAGGAAAGGGGGGACATAAATTAAT TGACTTTCTATTCCCAAAATGGGCTAGTTATATCAAATAAATACTCCCACTGCCCTTTCTGAGTGAGAG TGTTTCTCATAAGTCAAAAATTTCTGTTTACTCATTAACTACTCTTTGCAACAGGCTTTCATATAGAAG TATTCTGTTTATTTTTGCTGAGCCTAGATTGAGTAATTCTTAGTTTACAGAAGCTCCGAGCTTAATGAT AAGGATGAAAAGCAGAGGGAGCAATATAGAAGCAGGCTTGCTAATAAAACTTTTTAAATAATTGACAAG GGAATATTATGGAATGTGATGCAAAGTTTGTTCCGAAATTTTATGAGGAAATTACTCTCTAGTCTCACT TTATAGTCTTTTTGCTATGACTTTGAAGACCATTGATTTTTGAGAAGCAGAATAATAGGATTGCCTTTC ATTGCCCTATAGTGCAAAGAAGGTATATGCTTTATAACCAATGTTGTACTTTTGCCTAGAAAAACAAGA TATGGCTTTAAATAGCTACAATCATCTTTGGATGTATATGTCACTGCTGCTTCAAGTTATTGGATGCAT TTGAACCTCTGAGTTTGTCTTTCATTTTAAATATTGTCTGTTCTTTTAAATAAACAACCACAGATGTCA GGAAAAAGTCTTACCTTGTCAACTGGTTGCTCCACTTTTTAAAAATGATTGAATGATAACATCATATTA ACTGCGTTTTACTATACTTACAGAGTCACCTAAGGTCCTGCGAGTACAAGGGTCGACCCCCAAAGGCAG GGGCAGAGCCAGCATCTGAGAGGGAGGTCTCTTGACCAATGGGCAGAATCTTCACTCCAGGCACATAGC CCCAACCACCTCTGCCAGCAACCTTGAGAGGAAGGACAAGAAGAAAGATGGGATAGAATTTAAATAGAG AAGAATGCCATTTTATCACTCTGCCTCTGGGTGAAATAAAGATCAGTCTTGATGTTCTAACTCTAATTC ACAGTGGTCTCCTTTCAGCCCTACCCATTCTGCAGCAAATTCCAGCTGGTCAGAGAGTCAGTGCTGTGG CTCTGCCATGGAGGCTCATAACCCAACACTGGAACATTCCCTAGCCAAGGCAGAAGTCCTTAGGCGGGA CTTCCTTACCACCACGGGTGCTAAAAGAAGAGTTAGTAGGTCATGCTTCTACCAGTAATCTAAGGACTC TCTCCTTCTCTTCTTCCTCTTTCTCCAGATTTCCAAGCCTTAGCTAAGAGTAATTTGGCTTGTTTAGTA TTGTTTTCTTATGGTCCAGTTAATTACCAAAAATATTTTTAAAATCATCTCTGTTAATAGAATGTCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001102416.3
Synonyms	BDK; BK; HAE6; HMWK; KNG
Summary	This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]
Locus ID	3827
MW	76.1

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