PRCP (NM_199418) Human 3' UTR Clone

Specifications

Product Data
Product Name	PRCP (NM_199418) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HUMPCP; PCP
ACCN	NM_199418
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC207473 3’UTR clone of NM_199418 The sequence shown below is from the reference sequence of NM_199418. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCA CACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTG ATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTC CTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTG GCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCT GCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTA CCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGC CAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAAT AATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAACTCCGGCTGATGGAAATGCT GTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTT AGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTT TGTTTCTAAGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTT TAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGA ATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCTGATA GTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGT ATGACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCC ATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTT TCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCAGGGACACAGAGAGACAGAGAGAGAGAGACTAA CAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTT CTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGC ATTTTTTTTTTTTAAGGGCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAAATATTTCCTTTACTT TCCCTGGCATCTGGGAGATACAGGAAAATCTTTGTCTTATTTTGGGAGCCTTCAGTTCTCATTGTAATG AGTTGTCTATCAAAGCATTTGGTAACTATTTTGTTTCAGCATCACAGAACAATCGATTTGGGTGGGAAT TTAAGGGCCAAAACAATACTAGTTTTTATTCTTTGTCAACTAAGAAATTAAATAATGCAGGGTTTATGG GCTCAATAGAGGATATTCTTACAATTTATTTTACGATTTTAGGGTTTTTCCCTTGTGTAGAATCTTTAA AATACTTTGCCATTTTATTTGATGTTGATTATTTGGATGAGTTACATTATTCTGAAGAAACAAACTGCA AAAAATAGAATTTTTTGGCAAGCATAATTGTATCCTATTACTGTATGCATTTTAGGAATATAGATAGCA GCCTTAATTGAAGTGAGTATAATTATAATATGCTAAGGTTTAATTTTAACATGAAAAAGAATTGGAGTG TCAGATAAGCCTTATTATTTAAAGCATCCCTCTAATAAAACTGCACTTTTTACTGACAGGGAAAGAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_199418.4
Synonyms	HUMPCP; PCP
Summary	This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Locus ID	5547
MW	76.8

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