FKBP12 (FKBP1A) (NM_054014) Human 3' UTR Clone

Specifications

Product Data
Product Name	FKBP12 (FKBP1A) (NM_054014) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	FKBP-1A; FKBP-12; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
ACCN	NM_054014
Insert Size	417 bp
Sequence Data	Insert Sequence (showhide) >SC205447 3' UTR clone of NM_054014 The sequence shown below is from the reference sequence of NM_054014. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC ATGCCACTCTCGTCTTCGATGTGGAGCTTCTAAAACTGGAATGACAGGAATGGCCTCCTCCCTTAGCTCC CTGTTCTTGGGTAAGGAAATGGAATACTGAAGGGCCCTTCACTGCCTTTGCTCCTCCCATGTTATGCCCA GCGTTTGATGGGTAGCAGAGAGAACAAAAAACACCACAAGGCTATTTTTCCCCCTGCATTCTTTCTGTAT TGAGTATCCTTTCAGTGTTATTAGTGTATGCTTTGAATGTAAAAATTGGTCACCCTAAGGAAAGGAATTG GCATGTGTATGTTCCCAGTTCAACTCATGGAGATGGCAGCTGTTTAAATGTTTTTCTATGTAGTTTATAA ATTAAAACTGAATTGAGGACTATGGAAATGTAGGCCAAATTTGTAGTGCCAACATTTTAGTTCTTTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_054014.2
Synonyms	FKBP-1A; FKBP-12; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
Summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Locus ID	2280

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