Cathepsin L (CTSL) (NM_001912) Human 3' UTR Clone

Specifications

Product Data
Product Name	Cathepsin L (CTSL) (NM_001912) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CATL; CTSL1; MEP
ACCN	NM_001912
Insert Size	392 bp
Sequence Data	Insert Sequence (showhide) >SC205087 3’UTR clone of NM_001912 The sequence shown below is from the reference sequence of NM_001912. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCCTCAGCAGCCAGCTACCCCACTGTGTGAGCTGGTGGACGGTGATGAGGAAGGACTTGACTGGGGATG GCGCATGCATGGGAGGAATTCATCTTCAGTCTACCAGCCCCCGCTGTGTCGGATACACACTCGAATCAT TGAAGATCCGAGTGTGATTTGAATTCTGTGATATTTTCACACTGGTAAATGTTACCTCTATTTTAATTA CTGCTATAAATAGGTTTATATTATTGATTCACTTACTGACTTTGCATTTTCGTTTTTAAAAGGATGTAT AAATTTTTACCTGTTTAAATAAAATTTAATTTCAAATGTAGTGGTGGGGCTTCTTTCTATTTTTGATGC ACTGAATTTTTGTGTAATAAAGAACATAATTGGGCTCTAAGCCATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001912.5
Synonyms	CATL; CTSL1; MEP
Summary	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]
Locus ID	1514
MW	14.9

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