HAAO (NM_012205) Human 3' UTR Clone

Specifications

Product Data
Product Name	HAAO (NM_012205) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	3-HAO; h3HAO; HAO; VCRL1
ACCN	NM_012205
Insert Size	378 bp
Sequence Data	Insert Sequence (showhide) >SC204913 3’UTR clone of NM_012205 The sequence shown below is from the reference sequence of NM_012205. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACCCTGCCTGCAAGAAGCCCCTGGGGTGACCCTCTTGCCATGGCCTGAAGCAGCCACAGGTGTGCCAA GCACCCTCGAGTGCCATCCCTGCCAAACAACTCTCCCAGCCCCCACTACCTCTCTGTGTACTGCCGCTG TGTCCCCCACAGACCTGCACATTGTTGTCACCCACCCTCCTGCCCTTCTCAGCCCAGATGCCATGCCCC TGGGCGGGCAGCAGCTCCCCATCTTCTCTGGCAGACTCAGCCCACTGCCTTGCCAGTCTTGCCAGGTGG TCTACCCCCGGCCCCGCTCCTGCCCATTCCTCTGTCCCTGCAGACTCAGTGCAGCACTTCCACACCAAG AAGGCCCTCAATAAAGGCTTCCTGAGGAACGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_012205.3
Synonyms	3-HAO; h3HAO; HAO; VCRL1
Summary	3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Locus ID	23498
MW	13.1

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