DCTN1 (NM_004082) Human 3' UTR Clone

Specifications

Product Data
Product Name	DCTN1 (NM_004082) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DAP-150; DP-150; P135
ACCN	NM_004082
Insert Size	374 bp
Sequence Data	Insert Sequence (showhide) >SC204848 3’UTR clone of NM_004082 The sequence shown below is from the reference sequence of NM_004082. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CACCAGCTTCACAGTCGCCTCATCTCCTAAGCACTCCTTTCCCCTGCTGTCCCCTTCGACCCTCAGCCC TCTGGTGCCGCTCTGCCCGATGCACAGCCACCTCAGCCAGCCCCCAGGTAGAAACGTGGGTTAAGCTCT TCCTGCCCCGTTCAGCTTCACTCCCACCCTTTCAGCGTCCTGCCCCTTCACCTTGACCCGGGTTCCCCC ACTCCCATTCCCTGGCCTCTGCCATAATTTGTTGTTCAACTGCTCCCTCCTTCCTGAGGGGCCTCAGGG CTTGTGGGGGGTAGGCTGAGACCCCACCACCAAAGGTTAAGTGAGGTCCCCTTGATTGAGGACTTCACC CCTTGATTAAAGCAACTTCTGCTTCAGTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004082.5
Synonyms	DAP-150; DP-150; P135
Summary	This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Locus ID	1639
MW	13.4

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