TXNRD2 (NM_006440) Human 3' UTR Clone

Specifications

Product Data
Product Name	TXNRD2 (NM_006440) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GCCD5; SELZ; TR; TR-BETA; TR3; TRXR2
ACCN	NM_006440
Insert Size	381 bp
Sequence Data	Insert Sequence (showhide) >SC204777 3’UTR clone of NM_006440 The sequence shown below is from the reference sequence of NM_006440. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCC GCCAGCTCCTCGGAGGCCAGACCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGG AGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACAGGTGGCCCGTGTGCCCCACAGGGATGG CTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCAGGCTCC TGGTGCCAGATGATGACGACCTGGGTGGAAACCTACCCTGTGGGCACCCATGTCCGAGCCCCCTGGCAT TTCTGCAATGCAAATAAAGAGGGTACTTTTTCTGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006440.5
Synonyms	GCCD5; SELZ; TR; TR-BETA; TR3; TRXR2
Summary	The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Locus ID	10587
MW	13.4

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