COP1 (RFWD2) (NM_022457) Human 3' UTR Clone

Specifications

Product Data
Product Name	COP1 (RFWD2) (NM_022457) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CFAP78; FAP78; RFWD2; RNF200
ACCN	NM_022457
Insert Size	352 bp
Sequence Data	Insert Sequence (showhide) >SC204688 3’UTR clone of NM_022457 The sequence shown below is from the reference sequence of NM_022457. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGTACAATTAAGGTGCTAGAATTGGTATGAAGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAA ATACATCTGCAGCTGACAATGAGAGAAGAAACAGAAAATGTCATGTGATGTCTCTCCCCAAAGTCATCA TGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTTCCCTCCTTTATGACCTTTGGGACAT TGGGAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTGTTAT CTAATTTTTGTGATAGGGAAACAAATTCTTTTGAATAAAAATAAATAACAAAACAATAAAAGTTTATTG AGCCACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022457.7
Synonyms	CFAP78; FAP78; RFWD2; RNF200
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).[UniProtKB/Swiss-Prot Function]
Locus ID	64326
MW	13.5

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