TTC35 (EMC2) (NM_014673) Human 3' UTR Clone

Specifications

Product Data
Product Name	TTC35 (EMC2) (NM_014673) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	KIAA0103; TTC35
ACCN	NM_014673
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC204515 3’UTR clone of NM_014673 The sequence shown below is from the reference sequence of NM_014673. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTGGAAACATTGCAGATCACCCAGTCTTAAGGTTTCAAAAACTCTTTGACATTAGATTTCACAACTGCA CAATTGAACTTATTGGCCTGTAACTTATTTACTAAATGCTCAGTGCTATTTATATACTACAGTAATTTT CTGTTAAGAAGGCAGTTGTAAAGAATGTGTTTATATAAACCTAAAAATGCCTTTTACTGCTAAGTGGGG AGATGGGGGAAATCCATGGAAGAGAGATTTAAGACTTATTGATTGTACATCAGTCTCTTCATATCACAT ATACATGTATATATATAAAACTCTAATGTAGTATAACCTTGTTAAATAAACCATGATGATTTATTAAAC TTGCATATGAAGATTCTAACTTCATTTTGTTATACTCACAGTGGATATATTGTTTAAGAACTCAGTTTC TAGTTAACTCCTTACTGGTGATAGCAAAGTCACAGCATATGTAGCTGACCGAAGCAGATTATTTTGACT TTGTTTATATTGTCGAATTGGATTTTGCTGTACATTCCAGTGGGCTATTTGAATTGTTTTATCTGCTGT AATATCCTTCTGATGAATCTTGCTTAAAATATGTCATTCTCCAAAGTTCAGCAATATTTCTTTGTAAAA TTTTTGTTTTGATATAGGACATAATTGAGATTTTTACATATAAAATGCCTTAAGATAAATATGTGTTAC GACACTTTAACTTTTATGCAAGTTATATTTATTGAATCCTTTAATAGTAAATTACATGAAAGAATATTA AAGAATCATAAAGAGTAGGGATTAAAGGGGTTGTAGTTATTTTTAATTTTGAAAAAAATAAGAAAATTA AAACTATCCTTAGAAACAAAAATGTTAAAATTTTCCTATTCTATCATTACCTTAGTTAGAATTTTTTAT TTTTCTCTTTTCATAATAAACAACCATTATGCTACCTTCAACAGTATTTGACATGTTTCAACAAAATAG AAGAGACTTGAAAGTTAAATTTCATTTAGACACAAATCAGTTTTTAAAATAGCAACTGTTCACCGCAAA TATTTATGGTATTTGTTTATAATAAATATATTTAAATTTATTTTTACTAAAAATATACAGAGGCATCTA CAGACTTGTCATTGCTGCTTTGGACAAGTGGGGATTGTGGAGGAATTGACAATCTAGAAGTGTTTAGAA AGAAAAGTATTGTCAATATCAGCTTCTTTTAACCTTTTGAATAGTTCTGCTAATAAATTATTCTCCATA TCTAGTCTAATCTTTCATATTACAGTCATTTTCGTTTTATTCTGCCACGAGTAATAGGCAGCTGATTAA TATATTCTGTGAAAGAACTCTTCTCATCTGAAGGTAATTCTCTACTAATCTTTATTACCACAAAGATCC CGTCTTTGTACACATGAAATTAGTAACTGCATTTTCAACATGATGAACCATTTGAAATTTACATTTTCT GTAAAGAAAATAGTGCCTGCACGTTGTTTCACTACCTTTTCCCCTTCAAACCTCCTCCCCGTCAGTCAC TGGATTAGTGTTTACTCTAGCAATTATATTTGTGTAATAAGTAATTCAGTGCCTCTTATAGCTGTCTGC CTTAGTTTCACTTTTTTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCAGGCTGGAGTGCAGTGA CGTGATCGCAGCTCACTGCAACCTCCTCCCGGGTTCAAGCGATTCTTGTGCCTCAGCCTCTGAGTAGCT GGGACTACAGGCATGTGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATG TTGGCCAGGCTGGTCTGAAACTCCTGGCCTCAAGTGATCTACCCGCCTCAGCCTCCCGAAATGCTGGGA TTACAGGCATGAGCCACTGAGCCTGGCCAGTATCACTTTATTTTTTCAAAATTTTAATAACTTCTTTCC AAGATTTTATATTTGTTAAGCACATTGCCAATCCTTAGTTATTTATAAACTTCAACTTAAATGTACTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014673.5
Synonyms	KIAA0103; TTC35
Summary	Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).[UniProtKB/Swiss-Prot Function]
Locus ID	9694
MW	78

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