TEX264 (NM_001129884) Human 3' UTR Clone

Specifications

Product Data
Product Name	TEX264 (NM_001129884) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ZSIG11
ACCN	NM_001129884
Insert Size	337 bp
Sequence Data	Insert Sequence (showhide) >SC204282 3’UTR clone of NM_001129884 The sequence shown below is from the reference sequence of NM_001129884. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCACTGCCCCTGAGAAGGGCAAGGAGTAACCCATGGCCTGCACCCTCCTGCAGTGCAGTTGCTGAGGA ACTGAGCAGACTCTCCAGCAGACTCTCCAGCCCTCTTCCTCCTTCCTCTGGGGGAGGAGGGGTTCCTGA GGGACCTGACTTCCCCTGCTCCAGGCCTCTTGCTAAGCCTTCTCCTCACTGCCCTTTAGGCTCCCAGGG CCAGAGGAGCCAGGGACTATTTTCTGCACCAGCCCCCAGGGCTGCCACCCCTGTTGTGTCTTTTTTTCA GACTCACAGTGGAGCTTCCAGGACCCAGAATAAAGCCAATGATTTACTTGTTTCACCTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001129884.3
Synonyms	ZSIG11
Summary	Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).[UniProtKB/Swiss-Prot Function]
Locus ID	51368
MW	12.3

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