E3 SUMO protein ligase PIAS4 (PIAS4) (NM_015897) Human 3' UTR Clone

Specifications

Product Data
Product Name	E3 SUMO protein ligase PIAS4 (PIAS4) (NM_015897) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PIAS-gamma; Piasg; PIASY; ZMIZ6
ACCN	NM_015897
Insert Size	1541 bp
Sequence Data	Insert Sequence (showhide) >SC203791 3’UTR clone of NM_015897 The sequence shown below is from the reference sequence of NM_015897. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTCCAGAAGGGCCTGGTGCCGGCCTGCTGACCCCGGCCGCACACTCGACTTTCCTGGTGCTCACCACGC AGAGGGGCACGGGCCAGCCTCGGGCGCAGAGGGAGGAGTGACCTTTCTTTTTCTTTTTATTGTCGTTCG TTTTGTTTTTCCACCCTTTTGCCTGGCTCCTGGCACCTGTACCTCTGGACTCTCCTATCGGGGGATTAA AAAAAAAAGTAAAATGACAAAAAAAGATACAAAAAAGAAAAATGAAACAAAAAAGTCAAACTCTTAAAA ACAAGGCCGGCCACCCACACAGCCGCCTCCCCGGCTGGAGTCCGAGCCGGGAAGGGGTAGTGGGCGGGA GGGACCAGGACGCCGCCCCGCGCCCTCCCCTCCGGATGCCCCGCCGCCCGCCGCCCTCTGCCCACGACC ATTCCAGCCAGTGCGCGGGGACCCGGGCGGCGGGCGGTGGGGCGCAGCCCCTCTCTGGCGACCACTTTG ACGTTTGTCTCTTCCTTTGCTTTTTCTCTGCAAATGCATCCTCGCCCAGAGACCCTCACGCGCCGAGCA GCGAGCGTTTTAGCCGAGAAGCCATGGAGTGGGTTGGGGCGGGGAGGGGCAGTAGGGTGGGGGGATGGG TGGGCAGGATGGGGGTACAGTGGGCGGCTGGGGAGGGTTTAGCCACAGATGTGTTGTATTTTTTGAAAG TGCAATAATTTGGTATTTTGAAGACCCGGCGTGTGGTCAGGAACCCCCGGGGAAGGCGGGGGCCCAGGG TGCGGCACCGTGTGGCGTGGGGGGGTCTCAGTTTTCTAGCCAGCTACCTCGGTAATTCCAATTCAGGTT AACTTCCCTACGGAACAGCACAGATGTCCACAGATGTCCACAGCTGCCGCCGCCGCCGCCGCCACCATA CCCCGGTCCTTGGGGCATGGGTTGCGGTCGCTTCCCAAGGGGCAGCAGGGACCCCGGCCACCCCGGCTC TCGGTTTGGGTTGATTCCTCTCCTTTTTGCTCTTGGTTTTCCGACGGGTACGAGGCTGGCCCGGCACCC TGTCCCCCGGGAGCCTCACTCTTCCAGCAGGACCAGACCAGGGGCCTCCTTCCTGTCCCCAGGCGTTCC CGGCCCCTCGCAGGCCCCACCCATGCCCTTGGCCTCAGGGTCCAACAACTGGGGGAGCTACCAGGGCTC TGCCTTCAGGAGCCCACAGCTGGGCACCCCCCTTGCCCCGCAGGAGACCGGGGCGCAGGCGGGGCACCG GCCTCACCTGGTTCTCCAACACCGCTGCCTGCGGTCTGTTTTGCTTTTGTCCTCCCCAGCCCAGAATTT TCCTTTGTATAAACAGAACTCCTAGTCAGGAAGCAATATCATTTCAGGTCTAAAGAAAGGGACGTGCAT CTGGCCGAGGGCAGTTCAGTCTCACTGCAGAGCCCGCAGCCCGCTGCGCAGCTCGGCCCCTCCCGCCCG CACGGGCAGCTGAAGGCCGCTGTTTTCTAATATTTGTATTCTAATTTAATTGTTTTTAAAAAATGCAAA TAAAAAAGGTCGAGGTGAAGCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015897.4
Synonyms	PIAS-gamma; Piasg; PIASY; ZMIZ6
Summary	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.[UniProtKB/Swiss-Prot Function]
Locus ID	51588
MW	55.1

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