WASP (WAS) (NM_000377) Human 3' UTR Clone

Specifications

Product Data
Product Name	WASP (WAS) (NM_000377) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	IMD2; SCNX; THC; THC1; WASP; WASPA
ACCN	NM_000377
Insert Size	295 bp
Sequence Data	Insert Sequence (showhide) >SC203562 3’UTR clone of NM_000377 The sequence shown below is from the reference sequence of NM_000377. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAAGATGAAGATGATGAATGGGATGACTGAGTGGCTGAGTTACTTGCTGCCCTGTGCTCCTCCCCGCAG GACATGGCTCCCCCTCCACCTGCTCTGTGCCCACCCTCCACTCTCCTCTTCCAGGCCCCCAACCCCCCA TTTCTTCCCCACCAACCCCTCCAATGCTGTTATCCCTGCCTGGTCCTCACACTCACCCAACAATCCCAA GGCCCTTTTTATACAAAAATTCTCAGTTCTCTTCACTCAAGGATTTTTAAAGAAAAATAAAAGAATTGT CTTTCTGTCTCTCTATAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000377.3
Synonyms	IMD2; SCNX; THC; THC1; WASP; WASPA
Summary	The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
Locus ID	7454
MW	10.8

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