AZIN2 (NM_052998) Human 3' UTR Clone

Specifications

Product Data
Product Name	AZIN2 (NM_052998) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp
ACCN	NM_052998
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC202912 3’UTR clone of NM_052998 The sequence shown below is from the reference sequence of NM_052998. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTGTCTTCACCCCAGCGAGCATCATGTGAGTGGGCCTCGTTCCCCCCGGAGAATCCCAGCGGGGCCTC AGAGATGCATCTGGGAGAGGTGGGGAAGATGGCAGGCAAGGGTACCCTTGGCCAGGACTCTGGTGCCCA CCCTGCCACCCCCGCGCTCCACCTGCAGTGTTTCTGCCCTGTAAATAGGACCAGTCTTACACTCGCTGT AGTTCAAGTATGCAACATAAATCCTGTTCCTTCCAGCTGTGTCTGCCTCCTCTGCAGTGCAAGGGGCCT GGTCAGCCAGGTGTGGGGGTGTTCTTGGGGTCTCCTTTGGTCTCCTTCCCACCTTTGTAAATATAATGC AAATAAATAAATATTTAGGTTTTTAAAAACTGCAGCGGAATCTGGCAGTTTGATTCACAAAGCAGCCTG GGCTAGGCCTGGGGCAGGATTTCCCCATCACTCACTGATGAGCCCACACCCTCTGCTTTAGTCCTGAGC CCTGGCTGCAGCGTGTGCCTCCCCCACTAGTACTCACCTTATCTGACTCATCTCTCTCCTCCTCATGGG CCTCCAGGCCTGGTGCCATAAGGAAGGGGCTGCTGTCAGGGACTGAGATGGGCAGTTACGTAGCTCATA ACTGGTGAATGGCCTTTGGGTCAGCCCAACACCCAGCTTAAGGCCTGGCCCAGAGTAGGGGCAATGGAG TATTTAACACAGCTGTGGAAATTCATACTGAAGATACAGAGCCAAGAAATGGGTGTGTGGGAGGTTTTG AGTGGACCCTGCACCCTTGCTCTCCCTGCAGGTTGGCAAGGCAGTCAGAGTAAAGCAGACACCTGGTGG TCGCTTTTGCTTCTTTGGGCAGTGCCTGTTAGAACAGGGCTGGCCACGGAGTATTGCTGTGTCCAGTGC CGACAGCCCTGGCATCCCCTGAGACTGGCAGTGCTTATCAGGACAAAGGCTCCTTCACACTGCCGGGTT CCCAAATTATGCCCCGGGGTGTGTGAGCTGTTGAGCAAAGGAGTTCAGATTTTAGAGTCCCCCTCAGTG GCTGCAGGGGACTCTAAATATTTTTCTGCTGCAATTAAAAGATTTGAGATGTAATTCATATGCAATCAT CAAATTCACCCTTTTAAATGCAGAAGCCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGA GGCTGAGGCAGGTGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTC TCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTATGTGCCTGTAATTCCAGCTACTCAGGAGGCT GAGGCAGGAGAATCACTTGAACAGGGAGGTGGAGGTCGCAGTGAGCCGAGGTTGCAGTGAGCCGAGATT GCACCACTGCACTCCAGCCTGGGCGACTGAGCGAGACCCTGCCTCAAATAAAGAAATAAATAAATAAAG TGGAGAAGTTAGTGGTTTCTGGTGTATTCAGAGTTGTGTAACCATCACCCTAGAAAGAAATCCCATACC CATTAGCAGTCACTCTCCATTTTTCCCATTCCCCAGTCCCTGATGACACAAATCTACCTTCCATCTCTA TGGATTTGCTTATTCTGGACATTGTATTGTGATGGATTTTCTATCTTCACTTGAGCTTCTCTCTAGGTA AGCCTGACCATCCTGCTTCAGTATCTCAGCCAGTCCTGGTGGGAACTGTACGTGGCTTTGAGGTCATCT CATGAGGCAATGTGGCATGGGTTTGGAGTGAACGAGGTGCTTTCTCAAAGCCAGGGGTGTCTCCCTTTT CCAGGTGGGATCTAGTTTTCGGTATCTTGACAATAAATAGGCTGAAAGCTTGGGACATCAAAAGACTCA GGGCAATCAGAAAGGGTTACTCTACTACCCCGTGATCCATCAAAGCCACGATTTACAGGTATTACCATG CCAGTAATTGTCTATCAGACTCTGAGACTTCTTCCATCTCAGATCTCCAAGCACTCATACTTCTTTTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_052998.4
Synonyms	ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp
Summary	The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Locus ID	113451
MW	73.8

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