TNNT3 (NM_006757) Human 3' UTR Clone

Specifications

Product Data
Product Name	TNNT3 (NM_006757) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	beta-TnTF; DA2B2; TNTF
ACCN	NM_006757
Insert Size	240 bp
Sequence Data	Insert Sequence (showhide) >SC202703 3’UTR clone of NM_006757 The sequence shown below is from the reference sequence of NM_006757. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGGCAAAGTCGGCGGGCGCTGGAAGTAGAGAGGCCAGAAAGGCCCCTCGAGGCAGAGACCCTCCGCC CTCTTGCACACCAGGGCCGCTCGTGGGACTCCACATCCTCCAGCCCCCACAATCCTGTCAGGGGCTCCC TGACAGTCCTGGGGGTGGAGAGGCCATCCCGGGGCGTCCCCCGCGTCTGTGTCCTTGCTGCCTTCATCC CCTGGGGCCTGTGAATAAAGCTGCAGAACCCCC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006757.4
Synonyms	beta-TnTF; DA2B2; TNTF
Summary	The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Locus ID	7140
MW	8.3

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